LNP presence is not synonymous with transfection! Endothelial surface exposure is a much more logical way to assess where nanoparticles end up, consistent with observed adverse events.
Hi Marc, I appreciate your scientific insights and ideas. I definitely agree that endothelial cells, especially those in small capillary beds with relatively slow-flowing blood should be the primary target for transfection. However, based on the data that I have reviewed I suspect that transfection of other cell types may contribute, to at least some extent, to adverse events as well; especially since there are so many different types of adverse events beyond the limited few that have been publicly acknowledged at this time (and based on immunohistochemical staining of spike in post-mortem tissues, etc). It seems to me that a lot of these questions could be definitively answered by a well-designed, expertly conducted set of biodistribution studies that assess all components (i.e., LNPs and mRNAs) and derivatives (i.e., the gene product; in this case, spike) of the shots. I, for one, along with some colleagues would be very happy to conduct such a study in mice and/or other animal models. However, it is my understanding that Canada is like many other countries, meaning that independent third-party scientists are not allowed access to official vials of the shots to conduct such studies. If I am wrong, and someone can get me vials that would not break academic rules, I would love to do these studies. I would just want to be sure that I could publish the results without getting into trouble for contravening some kind of legally binding contract.
Out of interest, how does the finding of mRNA in breast milk fit into your hypothesis? Again, I was shocked that all that was looked at in those studies was mRNA. I don't understand why they wouldn't have looked for spike as well. I also don't understand why the authors didn't look for evidence of transfection of cells in breast tissue to ascertain which ones, if any, had taken up the mRNA.
mRNA-loaded LNPs sitting in tissues throughout the body plus or minus pathogen-derived proteins could be a major problem when it comes to the proposed prolific use of mRNA shots in food-producing animals. There is the potential for major negative implications should people start consuming these products in meat, milk, and/or eggs in the absence of any research.
I presume the vast majority of the mRNA would be destroyed by then. It would be idiotic to vaccinate just before the slaughterhouse. Not too concerned by that. Beyond the potential animal suffering like us humans (let's animal right activists on it!), The health of these animals, their weight, the damage to their vascular system would mean at a macro level much worse yield, and so higher prices and lower quality meat, dairy and eggs.
Thanks for the comment. Good to hear from you. It's been a long time my friend.
One critical observation is the significance of the leakage away from the tissue (70-80% leaks at least). That shows that without pressure transfection in tissue is relatively ineffective. Again that supports the "bolus theory" which can explain further tissue transfection which happens, but isn't the main exposure area.
All pathologies fit into the Bolus Theory framework (including cancer: see my article on transfecting immune privileged stem cells and progenitors that's another can of worms).
Pathology #1 (Skipping Anaphylaxis) is arterial rupture following a highly concentrated transfection in the aorta/artery, 60,000 LNPs suffice to poke a 1cm diameter hole. Smooth muscle layer is left bare to decay, rupture occurs 4-5 mo later.
Pathology #2: Thrombosis and Thrombocytopenia, is caused by further dissemination of the bolus causing a 1,000 cuts (delayed activation bc of PEG erosion differences), longer wounds, overwhelming number of wound-located endothelial cells signal the need for coagulation, coagulation inhibitors are overwhelmed...
Pathology #3 is, again further dissemination into the organs, arteriole and capillary transfection causing more localised clotting (strokes), necrosis, and sometimes ultimately organ failure. Can happen in any organ, nerves, etc... heard of people having actually literally had vaccine-induced lobotomies!
Pathology #4: is again further dissemination of the bolus, to create a sieve in the endothelium, blood-tissue barriers letting pass through unwanted elements (amyloids, LNPs, immune cells, toxins, non-digestible nutrient by babies...) or out of the organ (hormones, immature immune cells). So yeah, if the blood-milk barrier is made permeable by the vaccine, LNPs, T-cells and other toxic product will reach the maternal milk.
Check out Kevin McKernan, he's managed getting his hands on vials...you know him right? or do you want me to send you his email and introduce you?
Also it is unreasonable how none of the studies have ever mentioned the bio distribution of LNP in articular cartilage and in any joints, as those are important tissues that makes up a significant percentage of the body.
Thank you Dr Bridle, I believe Kevin McKernan(Anandamide) have done testing for observing plasmid and dsDNA contamination in all Pfizer shots with whole batches of both Pfizer and Moderna shots he has obtained. He has been making posts about sequencing tests for those batches since February and he even provided the methods he used for sequencing.
Hey Marc long time no see, what do you think about Kevin McKernan(Anandamide)'s test about finding plasmid and dsDNA contamination in all Pfizer shots?
I am not surprised by the contamination as bio manufacturing at scale is complex. This shows the dystopia of public health authorities who wanted to roll this out at all cost.
It confirms the risk of gene modification, but frankly I am not too concerned bc I doubt many will be touched (may be I am wrong but the probabilities should be extremely low).
The rest is irrelevant as these antigen-triggering LNPs are cytotoxic by nature, so adding anything that will kill the cell wouldn't change much. The mRNA would already damage the intracellular environment in immune privileged stem cells (the only that can theoretically survive this). Marginal additional damage could make it safer or more dangerous for cancer creation. Hard to tell.
What's interesting g is how biologists react to that news and buy into it, and not at all to my demonstration that 5% of the shots go outside the delivery protocol despite studies on mice and rabbits that show the exact same SAEs. Kevin's finding is scary-sexy and bio-based, my theory is physics-based (we don't want to know, we don't understand) and dull-unsexy (a trivial mistake in public health protocol).
Kevin is one of the rare good scientists I have encountered these past 3 yrs. His findings are very interesting, they could contribute marginally, and still within the construct of the Bolus Theory.
Our science community isn't trained at all in the scientific principles,it's quite shameful and dangerous. Millions of people are studying rabbit holes while no one is seriously taking care of the real issue killing our loved ones.
Still fighting but running out of steam I must admit.
I chat with Kevin all the time. we've been regularly interacting for 2 years now , at Panda first, with Steve Kirsch later and personally. He is one of the rare level-headed science guys around. Doesn't draw conclusion too early or without evidence. He is also very nice as a person.
I see. Is it possible for you to ask him if he can do an animal test with the mRNA vials he has to check the biodistribution of the LNP in tissues after intra-muscular injection to confirm if your statement that the endothelial cells are most transfected is true? Or ask him if he can find a lab or someone else who can do that with his vials?
I highly commend both Marc and Dr. Mike for their integrity and dedication and compassion during this ongoing period of catastrophic blunders .
I have read most of Marc's well written substacks and listened to at least two of his interviews.
And the same applies to the output of the redoubtable Dr. Yeadon.
And I have read about as much as I can about the multiple layers of damage caused by the jabs.
So that would make me approximately one ( 1 ) % as knowledgeable as these two.
But it seems to me that most of which Marc writes relates to his belief that the adverse effects of the jabs are mostly caused by an improper method of injection ?
He may or may not be right about that , but is it not that the Big Picture is the major harm done by these vaxxxes is in sidelining the innate immune system of those who made the mistake of getting such jabs, and therefore these will be extremely at risk as more virulent and lethal mutants evolve,, which as Geert predicts will be inevitable and, as he also predicts will happen sooner rather than later ?
Thanks for the faithful readership and this interesting comment. Let me respectfully bring a different perspective to the points you are making.
(1) I don't have a belief, I have worked from the clinical signs up: observing the facts, the data, measuring and calculating more data from those, ideating hypotheses, validating some and invalidating other. Through that process I built a theoretical construct that is very robust, and is validated 100% with the exception of the recent cancer creation hypothesis. And it just sio happens this construct explains cohesively all the AEs we are witnessing, and even other natural and medical accidents outside of vaccines like bee stings, toxin filler injections, anaesthetic... The materiality of accidental IV is proven and in line with the number of AEs. It is also consistent with the fact that many are fine and some aren't. Studies of IV injections in mice and rabbit of these vaccines or other similar products, have shown to produce the same adverse events. The Bolus Theory is consistent, factual and not conjectural, contrary to all the other theories which are still at the imaginative and conjectural stage, and for which I found falsifiable hypotheses that prove them wrong. (For example: why would quality problems mRNA vaccine for COVID, have the exact same AEs as an attenuated virus vaccine or a pseudo-virus vaccine against another target?" makes absolutely no sense, except for the injection technique).
(2) Geert's prediction have been completely wrong over and over again. The tragedy he described 2 years ago never happened. Neither the toxification of the viral strain, nor the innate immune system shut down have occurred. Geert is certainly not big picture: his innate system theory doesn't explain arterial rupture, nor thrombosis, and certainly not vascular leakage or organ damage. Biology is about immediacy, he is doing a Climate Change prophesy on us...so far none of his doom's day prophecy have occurred. And it was predictable. The idea that a simple vaccine inoculated a few time would trick the immune system is preposterous. Imagine how often nature has trialled that, in much more creative ways, and we are still alive. Some people lose part of their immunity (shingles...) and regain it...which is a very important clinical sign. PART, not all. TRANSIENT. The immune system doesn't work that way. VAIDS is most likely explained by blood-bone marrow barrier temporary damage and leakage of immature immune cells which reduce some of the immune capacity. The Bone Marrow being distributed, it is resilient.
Contrary to Geert, my predictions on sterility (I wrote before the first studies on sperm count in Israel about the risk of T-cell attack on spermatozoids in case of BTB permeability...) on milk poisoning , on neurodegenerative disease have all panned out...
Geert's theory is certainly not Big Picture, with all due respect. You are comparing a shattered house of cards with a lot of publicity, with a solid concrete building unknown to the world.
I apologise for my rant here, but Marketing isn't a sign of veracity. Facts, logic and consistency over time are.
I love your perspective, and as a layperson, it makes sense. I also agree with the premise that keeping our eye on the ball of this situation is important due to the implications for all vaccines. I do wonder, though, given the fact that EUA has allowed for a complete lack of transparency, if you have any thoughts about the possibility that pharma et al have taken this opportunity to introduce batches that potentially have nothing to do with Covid and have introduced other sorts of experimentation that would never fly under other circumstances. I don’t have anything in particular in mind, but I can’t imagine there isn’t a bit of free-for-all experimentation going on, given the once in a lifetime opportunity these institutions have granted themselves. It just seems like a third set of mechanisms could be involved whose results won’t be published maybe ever.
P.S. I love when scientists I wholeheartedly trust disagree. It’s the breeding ground for the greatest epiphanies. So grateful for all of you.
Well, first of all, that would be a clear violation of the contract. Not sure why they'd risk that. Second, even if they did do that, they have no control and limited feedback on who gets what, so any experiment would be very difficult to follow.
Frankly, most folks are not evil, and most aren't geniuses (am part of these folks), so I don't think that's what happened.
What's very clear is cognitive dissonance and dystopia on a grand scale had been happening around vaccines for ever: the idea that doctors cannot harm is old as the world, thus that vaccines are necessarily effective and safe, that means that the benefit/risk analysis is widely positive, and thus vaccine hesitancy is not acceptable, and to undermine vaccine hesitancy what better way than to hide and camouflage adverse events at an industrial level. COVID was the pinnacle of this medical and pharmaceutical dystopia: Vaccine hesitancy is unacceptable in that name any moral barriers can be crossed.
There’s a very strong linkage of batch and toxicity, at least early, that would support something(s) other than bolus being culpable.
Accumulation In pharmacodynamic studies does show preferential & time dependent increases in specific concentration in certain tissues such as ovaries, not necessarily the most highly vascularised or perfused. I think that indicates additional forces beyond passive are at play.
You may well be right broadly but people have been harmed in substantial numbers. Our explanations I believe seek explanatory mechanisms.
The batches apparent early correlation is simply because elderly were prioritized. Hence there's a huge selection bias bc we know that the elderly are much more fragile and susceptible to immediate deaths than the young. Quite normal.
The numbers are very substantial bc as I demonstrated in several articles the percentage of shots going in IV is much greater than anybody thought: 2% go IV with aspiration and well trained nurses (according to a 2015 study) , so 5% w/o aspiration and w/ untrained injectors is a reasonable estimate (in line with Pr Burkhardt).
With 13. 4bn shots, thats 670 million injured, 134 mn clinically injured bc (20% are more severe according to the same steroid shots study), likely 13 mn have already died (elderly and anaphylaxis), another 26 will die in next 5 yrs, and some 330 million are at serious risk of Alzheimer's and other neurodegenerative disease with immune senescence. Hard to estimate cancers but the exposure of the bone marrow is greater than the brain, but requires a bigger bolus than AD.
That's significant enough. This is unfortunately not new, we have been harming folks for ever by the same mechanism of harm.
I work on clinical data. Pr Iwasaki from Yale showed people who were having severe COVID had 25-50% dendritic cells vs normal. Nothing to do with genes, all to do with senescence (age).
This SC2 craze was a scam of epic proportion: a recent study from Italy showed COVID was there as early September 2019, 6,5 months before the crisis. Where were the dead bodies then?
Anecdotal evidence from my circle, but if similar AE happen with all vaccines, why would the 2nd dose of the mRNAs make people so much sicker than their first?
Did we all get a worse injection technique on our second dose? Doesn’t make logical sense to me, but I’m not in the science business.
Very simple the immuneis more robust bc the immune system knows what to attack for one, and 2 the damage of the first shot is accentuated with the second shot.
And yes, people Physiologie can mean they have multiple IV shots.
I am not assuming anything. LNPs get destroyed by the liver. There are traces of mRNA long term which are likely remnant of apoptosised transfected cells.
Interetsting Marc, and makes sense on several levels.
'Something' is the reason that not everybody injected gets a bad reaction. If it were as straightforward as 'whatever content in the vials is bad' then unless some vials have no 'content' we can not know.
I think it pays to keep open minded and ask rather than circle in our chosen echo chamber.
There's evidence from several studies that these vaccines and others injected intravascularly stimulate the same adverse events: heart, liver, thrombosis, thrombocypenia...
There are also several studies showing that even with methods to avoid IV, a significant number of them go IV.
Oh Marc I am not suggesting that you are in an echo chamber or that I think you are wrong. I have read what you say on this and accept it absolutely as very plausible - to the extent that I asked my injected contacts if any attempt had been made to aspirate before injection. I was more minded that some people are likely to dismiss what you say because they prefer to stay in their own echo chamber! I like to read and stay as open minded as can be.
I did have some sense of hope after reading this article, thank you.
I understand the desire to rationalise what has happened as some kind of massively important but under appreciated error.
It’s otherwise terrifying.
Unfortunately there’s so much evidence that in my opinion, any reasonable person, shown even part of the evidence, will be unable to maintain alternative views than that we are under extraordinarily serious attack globally by well-connected crooks (to put it mildly). Many find that the plot has such diabolical dimensions that they’re taken up Bible studies.
Once the pandemic illusion is destroyed by the evidence, there’s nowhere left to turn.
Here’s a discussion article dismantling that illusion.
Obviously, they have been hiding the damage and manipulating the data. Fauci trying to hide his misdeeds. Some people in Pharma have been obviously trying to minimize perception of harm for decades paying for biased metaanalyses, splitting harm in thousands of unreconciliable illnesses, and shaming "anti-vax ers" mothers whose self-preservation instincts were right. The crime against humanity is there, and it has been there for decades, we just saw it this time, bc they lost any sense of decency and ethics. The criminal charges are on pharma and corrupt public health who continued to push this massively despite the horrendous and sad vigilance data.
Yes, the damage is mind bogglingly huge, and the rush to inject carried on right up to the point of delivery, as I have seen in so many videos of injections. I absolutely appreciate the bolus effect and the need to inject slowly. On the two occasions over the past 20 years that I have injected my sheep either subcutaneously or intramuscularly I have done it very slowly, as it just makes basic common sense to me!
I do wonder though quite what it will take for society to learn the lessons. So many people have invested so much to accepting and believing the 'narrative as sold' that I am not sure if they will ever allow themselves to see a different truth, even if it is suspected.
I respect the inductive reasoning, but regarding "passive" "tissue"-resident LNPs, this part of the explanation seems incomplete:
The "vast majority of the particles stay idle for hours and end up leaking back into the blood stream via the lymphatic system." You write most "leak back into the blood stream." What is the basis for that assertion? Or is that some fundamental biology?
It's very possible the ovaries have a topology to retain and store nutrients as they are so precious. Doubt LNMs can pass the blood follicle barrier... But they can damage the BFB as they can damage the Blood Testis and Epididymal Barriers... Later on letting in the immune system.
That's irrelevant bc these mRNA, pseudo-viruses, or attenuated virus vaccine targeting Covid or other diseases, all stimulate the exact same adverse events...There's a common root cause.
An attenuated (weakened) pathogen or an extract of a dead pathogen is completely different from mRNA.
The first two are immunogens (give rise to a potentially useful immune response) & can be assayed precisely & a unit dose given.
That’s the most your immune system (or other parts of the body) can encounter.
mRNA on the other hand is not the immunogen. We don’t make adaptive immune responses against them, at least not predominantly. Until they chemically modified one of the bases, natural mRNA was so gossamer unstable that it’s probably not long lived enough to generate responses that take two weeks or more to emerge
Instead of a unit dose of an immunogen we’re given (the aim on paper if not quite the opposite in clinical practice) a unit dose of a message for an immunogen.
Even being charitable, the range of amounts of immunogen (in this case, by sheer coincidenc! Chosen by all four drug companies) elaborated from message encoding spike will be 100-fold more variable. I think more likely 1000-fold.
As I’ve already mentioned earlier, this process ends with autoimmunity and destruction of the cell expressing in this case spike. I’ve discussed this with a former professor of clinical immunology & they confirm that’s their expectation.
Also, injected proteins do not get processed & placed on the surface to be probed by our immune system. They therefore cannot trigger autoimmune responses.
Instead they get displayed in conjunction with major histocompatibility complex and it’s this our B-cells use for selecting clones for expansion as antibody secreting lymphocyte’s & cytotoxic T lymphocytes.
Gene based “vaccines” might have a place in a desperate, last ditch attempt to cause a huge immune attack upon a defined & irresistible cancer. Usually, that’s futile, because you’ve already generated the best immune response to those cancer proteins.
To give these materials to healthy but scared people was intended to harm, maim and kill at least some of them.
The mRNA vx triggers an apoptosis of the cells that express MHCs. Peptides are presented on the MHCs that trigger an immune reaction. Clearly CD8+ and CD4+ are attacking the transfected cells (shown in all studies and autopsies) and an adaptive response to these shots has been shown from the very beginning.
This is similar to what occurs with pseudo-viruses or with attenuated viruses that all also penetrate, and trigger an immune attack that destroys the cells penetrated by vaccine particles. Simply the antigen is brought in one case, and produced in-site in the other. Makes no difference to the extra-cellular immune system.
This explains calcification simply bc endothelial cells have been transfected and destroyed in large quantities, the calcification inhibitors are no longer produced by the endothelium in that area. It's very clear in Hong Kong study testing IV.
I agree with u that protein vaccines like the flu vaccine do not penetrate (except in rare circumstances) and thus don't trigger apoptosis. See the comparison in harm between the smallpox vx (transfecting) and the flu vx (non transfecting) Engle et al, I shared in on eod my papers.
Can a protein vx create apoptosis or trigger cell death? Most likely by saturation created by a large Bolus, the proteins would get pushed in, and trigger the same answer, but that would occur only with a massive bolus, and explain why even the flu vaccine harms occasionally.
I have answered the circulating spike theory in "Lifting the Fog on Decades ..". The circulating spike theory is falsifiable in 12 ways, the most obvious of them being "Antibody effectiveness".
Happy to share with you articles showing T-cell infiltration (Pr Burkhardt shows that in every of his autopsies), the HK study also and many others. One study even shows CD4+exhaustion with PD-1 expression in myocarditis patients which also proves a Bolus bc a Bolus improves transfection effectiveness, znd so more work for CD8+ and CD4+.
I am not in any stating the mRNA are justified, they were always useless and a scam.
As to your point on cancer, therapeutic vaccine can be useful in permanently triggering a response, ie building T-cells cohort that aren't being created bc the biomarkers are being hidden by the microenvironment to the immune system. U can also leverage more Lymph nodes and assemble larger cohorts of T-cells. But if you do that with too big a dose you deplete it, do it's idiotic. My friend DNA vaccine doesn't transfer T endothelial cells only DCs... So cohorts aren't wasted. There is hope there, by not with the Biontech or Moderna tech.
The so called spike protein™ is a key element or a key cover story for a key element.
As are the LNPs (which may generate what show up as s-proteins without 'transfection' occurring)
I see all trending to install 'transfection' via mRNA therapy in the minds of the Many, using shock of associating damage TO its cause. You might think this undermines its ability to become a new operating system for farming sickness in human beings, but consider pharma sells its products with terrible side effects as 'powerful drugs'.
The breakdown of the structured gel water lining endothelial cells is an electrical effect. See Gerald Pollack's work on the EZ exclusion zone negatively charged liquid crystal water adjacent to hydrophilic surfaces.
Alas insiders utilise cutting edge science for marketising or weaponising private gains such as to limit mainstream understandings to protect their insider dealing against disclosure.
Not everybody is harmed. One needs to recognize that!
Normal conditions are a true intramuscular injection done slowly.
Have been fighting this more than anyone and for more than 2 years. But scaring everyone when it's not needed is being as mean as the other side.
Up to 5% of shots are done outside the protocol, that's crazy and criminal enough. Turning a blind eye on that is criminal. But scaring the shit out of everybody is evil, specially it's not true.
Those were never needed agreed, and some folks deserve prison or whatever the Law states, but the data is the data. And it is reassuring for some.
It’s definitely true that most are not harmed, as far as we can tell.
Like, no adverse effects. I know people who’ve had four & no adverse effects.
There’s no question that the products are EXTREMELY variable in composition and quality of what’s in them.
Hedley Rees (Substack) has longer in manufacturing complex biological products than I do in research. He explains in his writings how it’s literally impossible for them to have manufactured consistent products.
I believe that inherent variability plays an important role in defining toxicity.
Several other factors matter, too.
Regional deposition.
Differential uptake.
Hugely variable expression levels
Variable duration of half maximal levels.
Responses to the products.
Sum the variability & we find few die early some later and most survive.
Injury is the objective.
There’s no way responsible R&D teams would elect these designs.
I’ve been in “rational drug design” for over 30 years and I also have a formal training in toxicology.
So I’m not just making it up.
ANY product consisting of mRNA is axiomatically dangerous.
Autoimmune attack upon every cell taking up the message encoding non self proteins is axiomatic to immunology.
I think it’s unlikely that the injected material was ever polydisperse. Rather, a high proportion of the total dose is likely to be found in clumps of particles. Imagine if instead of being perfect particles they were clumped in 3s, 10s, 30s, 100s of particles etc?
That’s likely because energetically it’s favoured & the contract manufacturers had neither the brief nor time / money to do anything about it.
Please: from a career scientist who wax at senior level in pharma and biotech, it’s not possible to create a safe and effective product like this AT ALL, made up of what we’re told they contain. It’s not even possible to make consistent product in a few months. Defining the endpoints and standards alone would take longer than they had.
Also, we know the drug companies had almost nothing to do with their manufacture. Contract manufacturers did the work and they were mostly established by shall we say spooks? Over the previous few years & decades.
We now know it was US military who placed the orders, and they did so using a legal on paper method of “Other Transaction Authority”. This is the framework they use for acquiring weapons systems.
If you’ve not read Katherine Watt and Sasha Latypova on Substack, you won’t know what they’ve uncovered.
I knew this was an attack upon humanity early on.
I knew several experts I personally know lying to us all through the TV.
They’ve done nothing BUT lie. I can’t find one substantive point about the alleged pandemic, countermeasures of the alleged vaccines that isn’t a lie.
My which I mean a huge difference between claim and reality that the person saying it knew to be present.
Thank you Marc for answering so many readers questions with incredible detail. We are all so fortunate that you are prepared to keep explaining and presenting these research findings. I can't tell you how many times people have asked me why everyone is not harmed if the spike and LNPs are so dangerous.... You continue to answer the questions being asked and I am yet to find anyone with evidence to disprove the aspiration or bolus theory.
We all need to share your substack far and wide. Even though it's often incredibly technical, your summaries and key points have been particularly helpful for those of us just trying to understand and share the key ideas and mechanism of harm ( as well as the potential/ fortunate escape from harm). Everyone knows people who are completely fine after various vaccines as well as people (less) who have been irreversibly harmed by mRNA vaccines. Either way you have a strong case for staying away from these vaccines and some people are simply oblivious they have just incredibly lucky they avoided harm. But this all seems in the end a frightening and risky game of roulette unimagible in the pre covid world. Hopefully your research will continue to save more lives as more people learn the truth and risk of IV injection. Thanks again for a really exceptional substack as well as an interesting and comprehensive set of discussion/comments. I've learnt many things from your answers to questions. Your interactions with Dr Yeadon were particularly enlightening and we the readers are lucky to have so many intelligent people engaging with each other. I hope you receive many paid subscribers to support your work now and in the future.
Gratitude Dr Yeadon . This new normal often feels like a maze of madness .... but reading the scientific discussion and general interaction bw those with specific expertise and those just interested to learn from serious, reliable research has been both enlightening and welcome reprieve from the sadness and frustration of what was once unimaginable insanity. I imagine that one day most people will also believe that risking IV injection and/or experimental products for a tiny baby is also unimaginable insanity.
We live in strange times and we are finding ourselves dependent on the honesty, integrity and sacrifice of a few of the brightest minds, the good guys to help us, the people, make responsible decisions, not just for ourselves but to protect and preserve the increasing fragility of future generations born and unborn. I can see you and Marc have both taken this incredibly seriously and it is greatly appreciated.
The dispersions are not homogenous. The EMA asked for samples from top, middle and bottom of the mixing vats. So doses can vary by vial. So some people got very few or no intact modRNA strands, others lots.
And there is aggregation and clumping of the LNPs due to pH and temperature changes.
Are you aware of the work of Christie Laura Grace who was a lipid nanoparticle expert working in the industry and had lots of great substack posts about what happens if the nanoparticles are positive or negative and the different places they then go and effects that follow? Unfortunately she has scrubbed her substack and Twitter so you can’t read these posts anymore but here is an interview she did a couple of months ago. Judging by her most recent substacks I received by email I might guess that she is suffering from a psychiatric illness leading to paranoia and I know others label her as difficult but her scientific work read as accurate to me.
I have had some exchanges, but she's been very rude.
And I have no patience for that.
I think overspecialisation is a disadvantage bc everyone wants their field to be relevant...I don't care I look at the data and the facts, and tehn come up with ways to explain them and test these hypotheses.
Here's what everybody forget. Each vaccine particle is cytotoxic.
So how can you make it more toxic?
I'd argue that bad QA would likely make the vaccines safer.
Finally, why would all vaccines even with different technology have the same adverse effects... They can't synchronize their mistakes? Better, why are the AEs the same than other va cinés like HPV, Hepatis, MMR... How does that make sense... Different manufacturing process, different technology and different target.
I forgot to add: products obtained under OTA do not have to comply with any of the usual niceties that FDA requires.
Technically & legally they were, per contract, “large scale manufacturing prototypes”.
FDA didn’t review or authorise them.
They played their part by pretending to review the pretend dossiers that the companies threw together.
Moderna, for example, fattened theirs up by duplicating a huge chunk of non clinical studies while leaving completely blank almost everything else.
These are pretend filings.
They’re military products and six billion people have been coerced into being injected with them.
Prominently involved are several families known to be eugenicists for decades.
Unfortunately they’ve only just got started.
The end game is mandatory digital ID & cashless CBDC.
Once in place, unless already completely excluded from usual buying and selling, they can & I believe will coerce people into repeated injections of mRNA, which they now claim is the new gold standard.
Each govt has already agreed business terms to acquire ten more such injections per citizen.
It won’t be for entertainment. I see no way to resist the obvious conclusion.
Even if I’m wrong about the end game, we’re close to totalitarian tyranny in many parts of the world and I’ve planned what’s left of my life on that basis,
Please help us get the message out. Please speak with Nick Hudson. I don’t presume to know exactly where his thinking now is, but I sense he’s converging on the above,
Until 2020, two less likely candidates for conspiracy theorist of the decade! Yeadon & Hudson.
Mike, I haven't spoken to Nick in some time. But we all agree something wrong has happened and some have been authoritarian and plan to be even more.
In large because corrupt scientists told politicians it was the end of the world...
I have stayed away from politics, but proving these fools we trust have been harming us for decades by their incompetency or/and their corruptness is the best way for people to gain self-preservation instincts back, and also to push back on any centralized power.
Would this perhaps explain why apparently some batches were more dangerous than others? It was because of the skill or otherwise of those doing the injecting?
All of this needs to be taken in the context that nobody need to be injected in the first place and that it was done for commercial and political reasons by the very same people who created Covid 19!
amidwesterndoctor shows it commonplace to use dosage gradients in vaccines, but for some time batches have been dispersed so as to make connection of damage or death with vax unlikely, and many covax were randomised/untraceable
i would reassure by limiting a fearful imagination running on unknowns. There are enough unknowns to fill Orwell's Room 101 - so dont. But aligning in health, integrity, self-responsibility is also key.
Interesting to hear how this analysis match up with the Burkhardt/ Lang autopsies, that found deadly amounts of Vaccine distributed spike in the diseased bodies.
As I understand the vax doesn't contain spike protein but is stated and sold as a manual or deliberate infection (trans) to hack cells into making s-protein.
I'm as sold on man-made viruses applied in solution to lab-leaked viruses as I am on transfection theory - ie don't accept them. So I have questions as to what the s-protein is - not what it set in backstory to serve as. How it comes about, how it is assayed or measured.
It seems that the spike pieces do their worst damage once in the bloodstream, but infections to not generate viremia except in severe cases. That surely would be a significant difference in natural vs synthetic spike exposure even if the proteins were identical.
The circulating spike was never demonstrated to be insufficient number to harm. Too many antibodies.
I ran the numbers, they cannot physically avoid the antibodies. The damage is done by the immune system as demonstrate din all autopsies and biopsies. And that immune cell attacking cells e pressing spike or possible contaminants (see Kevin McKernan findings).
Why the need to coerce groups which have traditionally been seen as vulnerable, such as children and expecting mothers to take the Mrna product and why we're all traditional avenues actively shutdown? Here in the west I believe the only option was the "novel gene therapy" product on offer?
Valneva were hoping to produce a traditional product and the UK government pulled the funding.This was never about improving our health and has left a never ending list of unanswered questions.What happened to any risk/benefit analyses and a narative that keeps unravelling? It was a scam from day one.
That may be the case but it still leaves the never ending list of questions.
I feel it a grave error to view the issues with the product as purely a medical one especially in context of everything that has gone on over the last three years.
They new in 2021 and no doubt long before that there were serious unresolved issues but ploughed on regardless and show no sign of stopping.Please provide a valid medical reason to inject 6 month old babies with there product of choice?
Perhaps it is the case that antivaxers were right all along and tgat no vaccine is safe. Injecting foreign material into the body has consequences that perhaps has not bern properly investigated or measured. Autoimmune disorders in the past can take decades to be properly diagnosed and by that time it is harder to associate them with a product given at any time. How does the incidence of autoimmune disease correlate with the increase in vaccines given
There are many different mechanisims that these products might harm a patien-LNPs is just one of them and who knows what harm a combination of those mechanisms might do? Our bodies were designed to fight infection we do not need vaccines - what we do need is access to good healthily grown food, access to clean water and contact with our natural environment for the solutions to our health lie not in pharmaceuticals but in the natural world that we form a part of. Stop trying to play God.
Thank you Marc, appreciate the response, one thing we totally need is open discussion.
That was one of the first causalities in this debacle, Brett Weinstein came up with the phrase "feeble narative" and the mass use of "conspiracy theorist" to discredit anybody who dared question "the science".
Hi Marc, I appreciate your scientific insights and ideas. I definitely agree that endothelial cells, especially those in small capillary beds with relatively slow-flowing blood should be the primary target for transfection. However, based on the data that I have reviewed I suspect that transfection of other cell types may contribute, to at least some extent, to adverse events as well; especially since there are so many different types of adverse events beyond the limited few that have been publicly acknowledged at this time (and based on immunohistochemical staining of spike in post-mortem tissues, etc). It seems to me that a lot of these questions could be definitively answered by a well-designed, expertly conducted set of biodistribution studies that assess all components (i.e., LNPs and mRNAs) and derivatives (i.e., the gene product; in this case, spike) of the shots. I, for one, along with some colleagues would be very happy to conduct such a study in mice and/or other animal models. However, it is my understanding that Canada is like many other countries, meaning that independent third-party scientists are not allowed access to official vials of the shots to conduct such studies. If I am wrong, and someone can get me vials that would not break academic rules, I would love to do these studies. I would just want to be sure that I could publish the results without getting into trouble for contravening some kind of legally binding contract.
Out of interest, how does the finding of mRNA in breast milk fit into your hypothesis? Again, I was shocked that all that was looked at in those studies was mRNA. I don't understand why they wouldn't have looked for spike as well. I also don't understand why the authors didn't look for evidence of transfection of cells in breast tissue to ascertain which ones, if any, had taken up the mRNA.
mRNA-loaded LNPs sitting in tissues throughout the body plus or minus pathogen-derived proteins could be a major problem when it comes to the proposed prolific use of mRNA shots in food-producing animals. There is the potential for major negative implications should people start consuming these products in meat, milk, and/or eggs in the absence of any research.
I presume the vast majority of the mRNA would be destroyed by then. It would be idiotic to vaccinate just before the slaughterhouse. Not too concerned by that. Beyond the potential animal suffering like us humans (let's animal right activists on it!), The health of these animals, their weight, the damage to their vascular system would mean at a macro level much worse yield, and so higher prices and lower quality meat, dairy and eggs.
Hi Byram,
Thanks for the comment. Good to hear from you. It's been a long time my friend.
One critical observation is the significance of the leakage away from the tissue (70-80% leaks at least). That shows that without pressure transfection in tissue is relatively ineffective. Again that supports the "bolus theory" which can explain further tissue transfection which happens, but isn't the main exposure area.
Aneurysms, arterial ruptures, arterial white clots all suggest considerable part of the transfection in the endothelium prior to the capillaries also. If you haven't read my September article: "When and How Can Vaccine Particles Hurt You?" (https://covidmythbuster.substack.com/p/when-and-how-can-vaccine-particles) and my recent piece on endothelial wound topology driving Thrombosis (https://covidmythbuster.substack.com/p/could-the-geometry-of-blood-vessel), I suggest you do. Think you will like them.
All pathologies fit into the Bolus Theory framework (including cancer: see my article on transfecting immune privileged stem cells and progenitors that's another can of worms).
Pathology #1 (Skipping Anaphylaxis) is arterial rupture following a highly concentrated transfection in the aorta/artery, 60,000 LNPs suffice to poke a 1cm diameter hole. Smooth muscle layer is left bare to decay, rupture occurs 4-5 mo later.
Pathology #2: Thrombosis and Thrombocytopenia, is caused by further dissemination of the bolus causing a 1,000 cuts (delayed activation bc of PEG erosion differences), longer wounds, overwhelming number of wound-located endothelial cells signal the need for coagulation, coagulation inhibitors are overwhelmed...
Pathology #3 is, again further dissemination into the organs, arteriole and capillary transfection causing more localised clotting (strokes), necrosis, and sometimes ultimately organ failure. Can happen in any organ, nerves, etc... heard of people having actually literally had vaccine-induced lobotomies!
Pathology #4: is again further dissemination of the bolus, to create a sieve in the endothelium, blood-tissue barriers letting pass through unwanted elements (amyloids, LNPs, immune cells, toxins, non-digestible nutrient by babies...) or out of the organ (hormones, immature immune cells). So yeah, if the blood-milk barrier is made permeable by the vaccine, LNPs, T-cells and other toxic product will reach the maternal milk.
Check out Kevin McKernan, he's managed getting his hands on vials...you know him right? or do you want me to send you his email and introduce you?
Also it is unreasonable how none of the studies have ever mentioned the bio distribution of LNP in articular cartilage and in any joints, as those are important tissues that makes up a significant percentage of the body.
Thank you Dr Bridle, I believe Kevin McKernan(Anandamide) have done testing for observing plasmid and dsDNA contamination in all Pfizer shots with whole batches of both Pfizer and Moderna shots he has obtained. He has been making posts about sequencing tests for those batches since February and he even provided the methods he used for sequencing.
https://anandamide.substack.com/p/dna-contamination-in-8-vials-of-pfizer
Maybe you can try contact him to ask if he can provide you some of the vials from the batches he has for further testings?
Hey Marc long time no see, what do you think about Kevin McKernan(Anandamide)'s test about finding plasmid and dsDNA contamination in all Pfizer shots?
https://anandamide.substack.com/p/dna-contamination-in-8-vials-of-pfizer
Kevin is a good friend.
And he is a very good scientist.
I am not surprised by the contamination as bio manufacturing at scale is complex. This shows the dystopia of public health authorities who wanted to roll this out at all cost.
It confirms the risk of gene modification, but frankly I am not too concerned bc I doubt many will be touched (may be I am wrong but the probabilities should be extremely low).
The rest is irrelevant as these antigen-triggering LNPs are cytotoxic by nature, so adding anything that will kill the cell wouldn't change much. The mRNA would already damage the intracellular environment in immune privileged stem cells (the only that can theoretically survive this). Marginal additional damage could make it safer or more dangerous for cancer creation. Hard to tell.
What's interesting g is how biologists react to that news and buy into it, and not at all to my demonstration that 5% of the shots go outside the delivery protocol despite studies on mice and rabbits that show the exact same SAEs. Kevin's finding is scary-sexy and bio-based, my theory is physics-based (we don't want to know, we don't understand) and dull-unsexy (a trivial mistake in public health protocol).
Kevin is one of the rare good scientists I have encountered these past 3 yrs. His findings are very interesting, they could contribute marginally, and still within the construct of the Bolus Theory.
Our science community isn't trained at all in the scientific principles,it's quite shameful and dangerous. Millions of people are studying rabbit holes while no one is seriously taking care of the real issue killing our loved ones.
Still fighting but running out of steam I must admit.
Also according to Kevin, what are those plasmid DNA and dsDNA coded for and what product can they generate?
My undertsanding is they are coded for spike...
Then I hope the body can neutralize those contamination products...did you ever had an interview with Kevin or talked to him?
Remember Mithridates.
I chat with Kevin all the time. we've been regularly interacting for 2 years now , at Panda first, with Steve Kirsch later and personally. He is one of the rare level-headed science guys around. Doesn't draw conclusion too early or without evidence. He is also very nice as a person.
I see. Is it possible for you to ask him if he can do an animal test with the mRNA vials he has to check the biodistribution of the LNP in tissues after intra-muscular injection to confirm if your statement that the endothelial cells are most transfected is true? Or ask him if he can find a lab or someone else who can do that with his vials?
I highly commend both Marc and Dr. Mike for their integrity and dedication and compassion during this ongoing period of catastrophic blunders .
I have read most of Marc's well written substacks and listened to at least two of his interviews.
And the same applies to the output of the redoubtable Dr. Yeadon.
And I have read about as much as I can about the multiple layers of damage caused by the jabs.
So that would make me approximately one ( 1 ) % as knowledgeable as these two.
But it seems to me that most of which Marc writes relates to his belief that the adverse effects of the jabs are mostly caused by an improper method of injection ?
He may or may not be right about that , but is it not that the Big Picture is the major harm done by these vaxxxes is in sidelining the innate immune system of those who made the mistake of getting such jabs, and therefore these will be extremely at risk as more virulent and lethal mutants evolve,, which as Geert predicts will be inevitable and, as he also predicts will happen sooner rather than later ?
Thanks for the faithful readership and this interesting comment. Let me respectfully bring a different perspective to the points you are making.
(1) I don't have a belief, I have worked from the clinical signs up: observing the facts, the data, measuring and calculating more data from those, ideating hypotheses, validating some and invalidating other. Through that process I built a theoretical construct that is very robust, and is validated 100% with the exception of the recent cancer creation hypothesis. And it just sio happens this construct explains cohesively all the AEs we are witnessing, and even other natural and medical accidents outside of vaccines like bee stings, toxin filler injections, anaesthetic... The materiality of accidental IV is proven and in line with the number of AEs. It is also consistent with the fact that many are fine and some aren't. Studies of IV injections in mice and rabbit of these vaccines or other similar products, have shown to produce the same adverse events. The Bolus Theory is consistent, factual and not conjectural, contrary to all the other theories which are still at the imaginative and conjectural stage, and for which I found falsifiable hypotheses that prove them wrong. (For example: why would quality problems mRNA vaccine for COVID, have the exact same AEs as an attenuated virus vaccine or a pseudo-virus vaccine against another target?" makes absolutely no sense, except for the injection technique).
(2) Geert's prediction have been completely wrong over and over again. The tragedy he described 2 years ago never happened. Neither the toxification of the viral strain, nor the innate immune system shut down have occurred. Geert is certainly not big picture: his innate system theory doesn't explain arterial rupture, nor thrombosis, and certainly not vascular leakage or organ damage. Biology is about immediacy, he is doing a Climate Change prophesy on us...so far none of his doom's day prophecy have occurred. And it was predictable. The idea that a simple vaccine inoculated a few time would trick the immune system is preposterous. Imagine how often nature has trialled that, in much more creative ways, and we are still alive. Some people lose part of their immunity (shingles...) and regain it...which is a very important clinical sign. PART, not all. TRANSIENT. The immune system doesn't work that way. VAIDS is most likely explained by blood-bone marrow barrier temporary damage and leakage of immature immune cells which reduce some of the immune capacity. The Bone Marrow being distributed, it is resilient.
Contrary to Geert, my predictions on sterility (I wrote before the first studies on sperm count in Israel about the risk of T-cell attack on spermatozoids in case of BTB permeability...) on milk poisoning , on neurodegenerative disease have all panned out...
Geert's theory is certainly not Big Picture, with all due respect. You are comparing a shattered house of cards with a lot of publicity, with a solid concrete building unknown to the world.
I apologise for my rant here, but Marketing isn't a sign of veracity. Facts, logic and consistency over time are.
Have a beautiful Sunday.
Marc,
I love your perspective, and as a layperson, it makes sense. I also agree with the premise that keeping our eye on the ball of this situation is important due to the implications for all vaccines. I do wonder, though, given the fact that EUA has allowed for a complete lack of transparency, if you have any thoughts about the possibility that pharma et al have taken this opportunity to introduce batches that potentially have nothing to do with Covid and have introduced other sorts of experimentation that would never fly under other circumstances. I don’t have anything in particular in mind, but I can’t imagine there isn’t a bit of free-for-all experimentation going on, given the once in a lifetime opportunity these institutions have granted themselves. It just seems like a third set of mechanisms could be involved whose results won’t be published maybe ever.
P.S. I love when scientists I wholeheartedly trust disagree. It’s the breeding ground for the greatest epiphanies. So grateful for all of you.
Well, first of all, that would be a clear violation of the contract. Not sure why they'd risk that. Second, even if they did do that, they have no control and limited feedback on who gets what, so any experiment would be very difficult to follow.
Frankly, most folks are not evil, and most aren't geniuses (am part of these folks), so I don't think that's what happened.
What's very clear is cognitive dissonance and dystopia on a grand scale had been happening around vaccines for ever: the idea that doctors cannot harm is old as the world, thus that vaccines are necessarily effective and safe, that means that the benefit/risk analysis is widely positive, and thus vaccine hesitancy is not acceptable, and to undermine vaccine hesitancy what better way than to hide and camouflage adverse events at an industrial level. COVID was the pinnacle of this medical and pharmaceutical dystopia: Vaccine hesitancy is unacceptable in that name any moral barriers can be crossed.
Thank you to both Marc and Mike for rich discussion. We appreciate both perspectives, thanks
Marc,
There’s a very strong linkage of batch and toxicity, at least early, that would support something(s) other than bolus being culpable.
Accumulation In pharmacodynamic studies does show preferential & time dependent increases in specific concentration in certain tissues such as ovaries, not necessarily the most highly vascularised or perfused. I think that indicates additional forces beyond passive are at play.
You may well be right broadly but people have been harmed in substantial numbers. Our explanations I believe seek explanatory mechanisms.
Dear Mike,
I hope this finds you well. Miss our chats.
The batches apparent early correlation is simply because elderly were prioritized. Hence there's a huge selection bias bc we know that the elderly are much more fragile and susceptible to immediate deaths than the young. Quite normal.
The numbers are very substantial bc as I demonstrated in several articles the percentage of shots going in IV is much greater than anybody thought: 2% go IV with aspiration and well trained nurses (according to a 2015 study) , so 5% w/o aspiration and w/ untrained injectors is a reasonable estimate (in line with Pr Burkhardt).
With 13. 4bn shots, thats 670 million injured, 134 mn clinically injured bc (20% are more severe according to the same steroid shots study), likely 13 mn have already died (elderly and anaphylaxis), another 26 will die in next 5 yrs, and some 330 million are at serious risk of Alzheimer's and other neurodegenerative disease with immune senescence. Hard to estimate cancers but the exposure of the bone marrow is greater than the brain, but requires a bigger bolus than AD.
That's significant enough. This is unfortunately not new, we have been harming folks for ever by the same mechanism of harm.
This needs to stop and is easily stoppable.
With all my friendship,
Marc
I work on clinical data. Pr Iwasaki from Yale showed people who were having severe COVID had 25-50% dendritic cells vs normal. Nothing to do with genes, all to do with senescence (age).
This SC2 craze was a scam of epic proportion: a recent study from Italy showed COVID was there as early September 2019, 6,5 months before the crisis. Where were the dead bodies then?
This was a scam and elderly folks were betrayed
Anecdotal evidence from my circle, but if similar AE happen with all vaccines, why would the 2nd dose of the mRNAs make people so much sicker than their first?
Did we all get a worse injection technique on our second dose? Doesn’t make logical sense to me, but I’m not in the science business.
Very simple the immuneis more robust bc the immune system knows what to attack for one, and 2 the damage of the first shot is accentuated with the second shot.
And yes, people Physiologie can mean they have multiple IV shots.
He's assuming that these LNPs get eliminated.
Nope. Moderna had issues before con-vid with multiple doses of the gene therapy.
LNPs build up and cause more and more issues.
I am not assuming anything. LNPs get destroyed by the liver. There are traces of mRNA long term which are likely remnant of apoptosised transfected cells.
Of course individuality plays a role:
- physiology might increase or decrease: musculature, BMI, genetic predisposition for different vasculature structure...
- if a family goes to the same vaccination area thye will have the same experienced or inexperienced injector
Marc, You will do for me! Thank you!!
Interetsting Marc, and makes sense on several levels.
'Something' is the reason that not everybody injected gets a bad reaction. If it were as straightforward as 'whatever content in the vials is bad' then unless some vials have no 'content' we can not know.
I think it pays to keep open minded and ask rather than circle in our chosen echo chamber.
Let's hope you are right eh...
Thank you.
There's evidence from several studies that these vaccines and others injected intravascularly stimulate the same adverse events: heart, liver, thrombosis, thrombocypenia...
There are also several studies showing that even with methods to avoid IV, a significant number of them go IV.
Both are factual. Read my previous articles.
Oh Marc I am not suggesting that you are in an echo chamber or that I think you are wrong. I have read what you say on this and accept it absolutely as very plausible - to the extent that I asked my injected contacts if any attempt had been made to aspirate before injection. I was more minded that some people are likely to dismiss what you say because they prefer to stay in their own echo chamber! I like to read and stay as open minded as can be.
I did have some sense of hope after reading this article, thank you.
Thank God there is some hope.. The damage is enormous, but we need to learn some lessons from this disaster. Aspiration is not enough.
Aspiration + slow injection should drop world illnesses dramatically... However bizarre this sound the data states it's true.
I understand the desire to rationalise what has happened as some kind of massively important but under appreciated error.
It’s otherwise terrifying.
Unfortunately there’s so much evidence that in my opinion, any reasonable person, shown even part of the evidence, will be unable to maintain alternative views than that we are under extraordinarily serious attack globally by well-connected crooks (to put it mildly). Many find that the plot has such diabolical dimensions that they’re taken up Bible studies.
Once the pandemic illusion is destroyed by the evidence, there’s nowhere left to turn.
Here’s a discussion article dismantling that illusion.
The two are not mutually exclusive, Michael.
Obviously, they have been hiding the damage and manipulating the data. Fauci trying to hide his misdeeds. Some people in Pharma have been obviously trying to minimize perception of harm for decades paying for biased metaanalyses, splitting harm in thousands of unreconciliable illnesses, and shaming "anti-vax ers" mothers whose self-preservation instincts were right. The crime against humanity is there, and it has been there for decades, we just saw it this time, bc they lost any sense of decency and ethics. The criminal charges are on pharma and corrupt public health who continued to push this massively despite the horrendous and sad vigilance data.
Yes, the damage is mind bogglingly huge, and the rush to inject carried on right up to the point of delivery, as I have seen in so many videos of injections. I absolutely appreciate the bolus effect and the need to inject slowly. On the two occasions over the past 20 years that I have injected my sheep either subcutaneously or intramuscularly I have done it very slowly, as it just makes basic common sense to me!
I do wonder though quite what it will take for society to learn the lessons. So many people have invested so much to accepting and believing the 'narrative as sold' that I am not sure if they will ever allow themselves to see a different truth, even if it is suspected.
Good work Marc, appreciated.
I respect the inductive reasoning, but regarding "passive" "tissue"-resident LNPs, this part of the explanation seems incomplete:
The "vast majority of the particles stay idle for hours and end up leaking back into the blood stream via the lymphatic system." You write most "leak back into the blood stream." What is the basis for that assertion? Or is that some fundamental biology?
The basis is that's what the nice study shows. You inject in the muscle and over 48 hours it trickles to the blood stream .
At 48 hours, the specific concentration of LNP in ovaries was still rising, in the leaked Japanese mouse study.
(Actually, I don’t know the nationality of the mice 🐁 🤗)
The mice were Canadian, I believe.
It's very possible the ovaries have a topology to retain and store nutrients as they are so precious. Doubt LNMs can pass the blood follicle barrier... But they can damage the BFB as they can damage the Blood Testis and Epididymal Barriers... Later on letting in the immune system.
I thought that we don't actually know the contents of the vials nor is it legal in most places to look.
So trying to narrow down the mechanisms of harm to only one of an unknown # of variables seems near impossible.
Or am I incorrect about vial contents and they have been independently verified?
That's irrelevant bc these mRNA, pseudo-viruses, or attenuated virus vaccine targeting Covid or other diseases, all stimulate the exact same adverse events...There's a common root cause.
Marc. Sorry, I can’t let that pass.
An attenuated (weakened) pathogen or an extract of a dead pathogen is completely different from mRNA.
The first two are immunogens (give rise to a potentially useful immune response) & can be assayed precisely & a unit dose given.
That’s the most your immune system (or other parts of the body) can encounter.
mRNA on the other hand is not the immunogen. We don’t make adaptive immune responses against them, at least not predominantly. Until they chemically modified one of the bases, natural mRNA was so gossamer unstable that it’s probably not long lived enough to generate responses that take two weeks or more to emerge
Instead of a unit dose of an immunogen we’re given (the aim on paper if not quite the opposite in clinical practice) a unit dose of a message for an immunogen.
Even being charitable, the range of amounts of immunogen (in this case, by sheer coincidenc! Chosen by all four drug companies) elaborated from message encoding spike will be 100-fold more variable. I think more likely 1000-fold.
As I’ve already mentioned earlier, this process ends with autoimmunity and destruction of the cell expressing in this case spike. I’ve discussed this with a former professor of clinical immunology & they confirm that’s their expectation.
Also, injected proteins do not get processed & placed on the surface to be probed by our immune system. They therefore cannot trigger autoimmune responses.
Instead they get displayed in conjunction with major histocompatibility complex and it’s this our B-cells use for selecting clones for expansion as antibody secreting lymphocyte’s & cytotoxic T lymphocytes.
Gene based “vaccines” might have a place in a desperate, last ditch attempt to cause a huge immune attack upon a defined & irresistible cancer. Usually, that’s futile, because you’ve already generated the best immune response to those cancer proteins.
To give these materials to healthy but scared people was intended to harm, maim and kill at least some of them.
Dear Mike,
The mRNA vx triggers an apoptosis of the cells that express MHCs. Peptides are presented on the MHCs that trigger an immune reaction. Clearly CD8+ and CD4+ are attacking the transfected cells (shown in all studies and autopsies) and an adaptive response to these shots has been shown from the very beginning.
This is similar to what occurs with pseudo-viruses or with attenuated viruses that all also penetrate, and trigger an immune attack that destroys the cells penetrated by vaccine particles. Simply the antigen is brought in one case, and produced in-site in the other. Makes no difference to the extra-cellular immune system.
This explains calcification simply bc endothelial cells have been transfected and destroyed in large quantities, the calcification inhibitors are no longer produced by the endothelium in that area. It's very clear in Hong Kong study testing IV.
I agree with u that protein vaccines like the flu vaccine do not penetrate (except in rare circumstances) and thus don't trigger apoptosis. See the comparison in harm between the smallpox vx (transfecting) and the flu vx (non transfecting) Engle et al, I shared in on eod my papers.
Can a protein vx create apoptosis or trigger cell death? Most likely by saturation created by a large Bolus, the proteins would get pushed in, and trigger the same answer, but that would occur only with a massive bolus, and explain why even the flu vaccine harms occasionally.
I have answered the circulating spike theory in "Lifting the Fog on Decades ..". The circulating spike theory is falsifiable in 12 ways, the most obvious of them being "Antibody effectiveness".
Happy to share with you articles showing T-cell infiltration (Pr Burkhardt shows that in every of his autopsies), the HK study also and many others. One study even shows CD4+exhaustion with PD-1 expression in myocarditis patients which also proves a Bolus bc a Bolus improves transfection effectiveness, znd so more work for CD8+ and CD4+.
I am not in any stating the mRNA are justified, they were always useless and a scam.
As to your point on cancer, therapeutic vaccine can be useful in permanently triggering a response, ie building T-cells cohort that aren't being created bc the biomarkers are being hidden by the microenvironment to the immune system. U can also leverage more Lymph nodes and assemble larger cohorts of T-cells. But if you do that with too big a dose you deplete it, do it's idiotic. My friend DNA vaccine doesn't transfer T endothelial cells only DCs... So cohorts aren't wasted. There is hope there, by not with the Biontech or Moderna tech.
So you haven't yet looked at the blood sludge resulting from the decrease of zeta potential to a loss of colloidal suspension.
https://amidwesterndoctor.substack.com/p/why-does-every-vaccine-often-cause
The so called spike protein™ is a key element or a key cover story for a key element.
As are the LNPs (which may generate what show up as s-proteins without 'transfection' occurring)
I see all trending to install 'transfection' via mRNA therapy in the minds of the Many, using shock of associating damage TO its cause. You might think this undermines its ability to become a new operating system for farming sickness in human beings, but consider pharma sells its products with terrible side effects as 'powerful drugs'.
The breakdown of the structured gel water lining endothelial cells is an electrical effect. See Gerald Pollack's work on the EZ exclusion zone negatively charged liquid crystal water adjacent to hydrophilic surfaces.
Alas insiders utilise cutting edge science for marketising or weaponising private gains such as to limit mainstream understandings to protect their insider dealing against disclosure.
"I have come to that conclusion a long time ago: in normal conditions, the Pfizer vaccine cannot harm"
"in normal conditions"? "normal"? as in the "normal" fantasy world of "safe and effective".
The reality, in the "as used condition", is vaccine injury, more vaccine injury, and more vaccine injury"
Hang on a minute.
Not everybody is harmed. One needs to recognize that!
Normal conditions are a true intramuscular injection done slowly.
Have been fighting this more than anyone and for more than 2 years. But scaring everyone when it's not needed is being as mean as the other side.
Up to 5% of shots are done outside the protocol, that's crazy and criminal enough. Turning a blind eye on that is criminal. But scaring the shit out of everybody is evil, specially it's not true.
Those were never needed agreed, and some folks deserve prison or whatever the Law states, but the data is the data. And it is reassuring for some.
It’s definitely true that most are not harmed, as far as we can tell.
Like, no adverse effects. I know people who’ve had four & no adverse effects.
There’s no question that the products are EXTREMELY variable in composition and quality of what’s in them.
Hedley Rees (Substack) has longer in manufacturing complex biological products than I do in research. He explains in his writings how it’s literally impossible for them to have manufactured consistent products.
I believe that inherent variability plays an important role in defining toxicity.
Several other factors matter, too.
Regional deposition.
Differential uptake.
Hugely variable expression levels
Variable duration of half maximal levels.
Responses to the products.
Sum the variability & we find few die early some later and most survive.
Injury is the objective.
There’s no way responsible R&D teams would elect these designs.
I’ve been in “rational drug design” for over 30 years and I also have a formal training in toxicology.
So I’m not just making it up.
ANY product consisting of mRNA is axiomatically dangerous.
Autoimmune attack upon every cell taking up the message encoding non self proteins is axiomatic to immunology.
I think it’s unlikely that the injected material was ever polydisperse. Rather, a high proportion of the total dose is likely to be found in clumps of particles. Imagine if instead of being perfect particles they were clumped in 3s, 10s, 30s, 100s of particles etc?
That’s likely because energetically it’s favoured & the contract manufacturers had neither the brief nor time / money to do anything about it.
Please: from a career scientist who wax at senior level in pharma and biotech, it’s not possible to create a safe and effective product like this AT ALL, made up of what we’re told they contain. It’s not even possible to make consistent product in a few months. Defining the endpoints and standards alone would take longer than they had.
Also, we know the drug companies had almost nothing to do with their manufacture. Contract manufacturers did the work and they were mostly established by shall we say spooks? Over the previous few years & decades.
We now know it was US military who placed the orders, and they did so using a legal on paper method of “Other Transaction Authority”. This is the framework they use for acquiring weapons systems.
If you’ve not read Katherine Watt and Sasha Latypova on Substack, you won’t know what they’ve uncovered.
I knew this was an attack upon humanity early on.
I knew several experts I personally know lying to us all through the TV.
They’ve done nothing BUT lie. I can’t find one substantive point about the alleged pandemic, countermeasures of the alleged vaccines that isn’t a lie.
My which I mean a huge difference between claim and reality that the person saying it knew to be present.
Thank you Marc for answering so many readers questions with incredible detail. We are all so fortunate that you are prepared to keep explaining and presenting these research findings. I can't tell you how many times people have asked me why everyone is not harmed if the spike and LNPs are so dangerous.... You continue to answer the questions being asked and I am yet to find anyone with evidence to disprove the aspiration or bolus theory.
We all need to share your substack far and wide. Even though it's often incredibly technical, your summaries and key points have been particularly helpful for those of us just trying to understand and share the key ideas and mechanism of harm ( as well as the potential/ fortunate escape from harm). Everyone knows people who are completely fine after various vaccines as well as people (less) who have been irreversibly harmed by mRNA vaccines. Either way you have a strong case for staying away from these vaccines and some people are simply oblivious they have just incredibly lucky they avoided harm. But this all seems in the end a frightening and risky game of roulette unimagible in the pre covid world. Hopefully your research will continue to save more lives as more people learn the truth and risk of IV injection. Thanks again for a really exceptional substack as well as an interesting and comprehensive set of discussion/comments. I've learnt many things from your answers to questions. Your interactions with Dr Yeadon were particularly enlightening and we the readers are lucky to have so many intelligent people engaging with each other. I hope you receive many paid subscribers to support your work now and in the future.
🤗
Marc is one of the good guys.
Gratitude Dr Yeadon . This new normal often feels like a maze of madness .... but reading the scientific discussion and general interaction bw those with specific expertise and those just interested to learn from serious, reliable research has been both enlightening and welcome reprieve from the sadness and frustration of what was once unimaginable insanity. I imagine that one day most people will also believe that risking IV injection and/or experimental products for a tiny baby is also unimaginable insanity.
We live in strange times and we are finding ourselves dependent on the honesty, integrity and sacrifice of a few of the brightest minds, the good guys to help us, the people, make responsible decisions, not just for ourselves but to protect and preserve the increasing fragility of future generations born and unborn. I can see you and Marc have both taken this incredibly seriously and it is greatly appreciated.
The dispersions are not homogenous. The EMA asked for samples from top, middle and bottom of the mixing vats. So doses can vary by vial. So some people got very few or no intact modRNA strands, others lots.
And there is aggregation and clumping of the LNPs due to pH and temperature changes.
Interesting. Did you know that the regulators played theatrical games & never actually authorised any of these c19 injections?
See Katherine Watt & Sasha Latypova.
Oh yes. I know
Are you aware of the work of Christie Laura Grace who was a lipid nanoparticle expert working in the industry and had lots of great substack posts about what happens if the nanoparticles are positive or negative and the different places they then go and effects that follow? Unfortunately she has scrubbed her substack and Twitter so you can’t read these posts anymore but here is an interview she did a couple of months ago. Judging by her most recent substacks I received by email I might guess that she is suffering from a psychiatric illness leading to paranoia and I know others label her as difficult but her scientific work read as accurate to me.
https://discernable.io/lipid-nanoparticles-the-real-danger-of-mrna-vaccines/
I have had some exchanges, but she's been very rude.
And I have no patience for that.
I think overspecialisation is a disadvantage bc everyone wants their field to be relevant...I don't care I look at the data and the facts, and tehn come up with ways to explain them and test these hypotheses.
Michael,
Here's what everybody forget. Each vaccine particle is cytotoxic.
So how can you make it more toxic?
I'd argue that bad QA would likely make the vaccines safer.
Finally, why would all vaccines even with different technology have the same adverse effects... They can't synchronize their mistakes? Better, why are the AEs the same than other va cinés like HPV, Hepatis, MMR... How does that make sense... Different manufacturing process, different technology and different target.
I forgot to add: products obtained under OTA do not have to comply with any of the usual niceties that FDA requires.
Technically & legally they were, per contract, “large scale manufacturing prototypes”.
FDA didn’t review or authorise them.
They played their part by pretending to review the pretend dossiers that the companies threw together.
Moderna, for example, fattened theirs up by duplicating a huge chunk of non clinical studies while leaving completely blank almost everything else.
These are pretend filings.
They’re military products and six billion people have been coerced into being injected with them.
Prominently involved are several families known to be eugenicists for decades.
Unfortunately they’ve only just got started.
The end game is mandatory digital ID & cashless CBDC.
Once in place, unless already completely excluded from usual buying and selling, they can & I believe will coerce people into repeated injections of mRNA, which they now claim is the new gold standard.
Each govt has already agreed business terms to acquire ten more such injections per citizen.
It won’t be for entertainment. I see no way to resist the obvious conclusion.
Even if I’m wrong about the end game, we’re close to totalitarian tyranny in many parts of the world and I’ve planned what’s left of my life on that basis,
Please help us get the message out. Please speak with Nick Hudson. I don’t presume to know exactly where his thinking now is, but I sense he’s converging on the above,
Until 2020, two less likely candidates for conspiracy theorist of the decade! Yeadon & Hudson.
Mike, I haven't spoken to Nick in some time. But we all agree something wrong has happened and some have been authoritarian and plan to be even more.
In large because corrupt scientists told politicians it was the end of the world...
I have stayed away from politics, but proving these fools we trust have been harming us for decades by their incompetency or/and their corruptness is the best way for people to gain self-preservation instincts back, and also to push back on any centralized power.
Also, referring to those who appear not to be harmed...YET...we just don’t know the long term effects of these injections. Which is terrible, I think!
Would this perhaps explain why apparently some batches were more dangerous than others? It was because of the skill or otherwise of those doing the injecting?
All of this needs to be taken in the context that nobody need to be injected in the first place and that it was done for commercial and political reasons by the very same people who created Covid 19!
amidwesterndoctor shows it commonplace to use dosage gradients in vaccines, but for some time batches have been dispersed so as to make connection of damage or death with vax unlikely, and many covax were randomised/untraceable
i would reassure by limiting a fearful imagination running on unknowns. There are enough unknowns to fill Orwell's Room 101 - so dont. But aligning in health, integrity, self-responsibility is also key.
Absolutely.
This is also to reassure some folks.
Interesting to hear how this analysis match up with the Burkhardt/ Lang autopsies, that found deadly amounts of Vaccine distributed spike in the diseased bodies.
As I understand the vax doesn't contain spike protein but is stated and sold as a manual or deliberate infection (trans) to hack cells into making s-protein.
I'm as sold on man-made viruses applied in solution to lab-leaked viruses as I am on transfection theory - ie don't accept them. So I have questions as to what the s-protein is - not what it set in backstory to serve as. How it comes about, how it is assayed or measured.
For the record, if the spike were so lethal, the virus would be very lethal. It isn't and never was. 0.1% IFR.
Antibodies do their work and protect us from that poison that's proven over and over. Our God given immune system protects us from the likes of Fauci
It seems that the spike pieces do their worst damage once in the bloodstream, but infections to not generate viremia except in severe cases. That surely would be a significant difference in natural vs synthetic spike exposure even if the proteins were identical.
Mark,
The circulating spike was never demonstrated to be insufficient number to harm. Too many antibodies.
I ran the numbers, they cannot physically avoid the antibodies. The damage is done by the immune system as demonstrate din all autopsies and biopsies. And that immune cell attacking cells e pressing spike or possible contaminants (see Kevin McKernan findings).
I’m afraid the evidence is against there having been a novel virus at all.
I didn’t originally think this.
But close examination of the all causes mortality data leaves me no choice but to amend my earlier position.
Put simply, the wrong aged people died in very large numbers & not the most elderly and frail as we have repeatedly seen in the past.
https://open.substack.com/pub/scottishunityedinburgh/p/scotland-the-pandemic-that-never?r=18rn19&utm_medium=ios&utm_campaign=post
Hello Dr Yeadon,
Have you seen this data?
Immunologically it was never novel given the shared epitopes with other coronas.
Poisoning came from care homes and hospitals where the doses were enormous, and the mistreatment were evident.
I believe the people who state it's been fabricated. Seems too many antigens well lined up for a spike...
My Bolus Theory matches perfectly with Pr Burkhardt finding... Actually he has mentioned IV injection early on.
Why the need to coerce groups which have traditionally been seen as vulnerable, such as children and expecting mothers to take the Mrna product and why we're all traditional avenues actively shutdown? Here in the west I believe the only option was the "novel gene therapy" product on offer?
Valneva were hoping to produce a traditional product and the UK government pulled the funding.This was never about improving our health and has left a never ending list of unanswered questions.What happened to any risk/benefit analyses and a narative that keeps unravelling? It was a scam from day one.
None of the alleged vaccines worked to save lives and in my view (over 30 years in rational drug design) they never were intended to.
I believe instead the objective was to injure, maim & kill.
Mike,
Breath of fresh air. You and Marc, both.
"I believe instead the objective was to injure, maim & kill."
In that order. All vaccines. As in 100% of them.
Meaning, we all spend too much time focusing on deaths, rather than the Injured & Maimed which outnumber deaths by .. a lot.
Also, maybe: "Sicken", Injure, Maim and Kill?
Traditional product are as dangerous when injected in IV...
That may be the case but it still leaves the never ending list of questions.
I feel it a grave error to view the issues with the product as purely a medical one especially in context of everything that has gone on over the last three years.
They new in 2021 and no doubt long before that there were serious unresolved issues but ploughed on regardless and show no sign of stopping.Please provide a valid medical reason to inject 6 month old babies with there product of choice?
I am with you there! 100%
These vaccines were never needed, effective nor fully safe.
I have written tons of articles on why.
And specially not for kids!!!!
This article isn't to forgive pharma and public health on their corruption.
It's to stick to facts and science, and to help bring light and some comfort to those who are now living in fear.
Perhaps it is the case that antivaxers were right all along and tgat no vaccine is safe. Injecting foreign material into the body has consequences that perhaps has not bern properly investigated or measured. Autoimmune disorders in the past can take decades to be properly diagnosed and by that time it is harder to associate them with a product given at any time. How does the incidence of autoimmune disease correlate with the increase in vaccines given
There are many different mechanisims that these products might harm a patien-LNPs is just one of them and who knows what harm a combination of those mechanisms might do? Our bodies were designed to fight infection we do not need vaccines - what we do need is access to good healthily grown food, access to clean water and contact with our natural environment for the solutions to our health lie not in pharmaceuticals but in the natural world that we form a part of. Stop trying to play God.
Amen
Thank you Marc, appreciate the response, one thing we totally need is open discussion.
That was one of the first causalities in this debacle, Brett Weinstein came up with the phrase "feeble narative" and the mass use of "conspiracy theorist" to discredit anybody who dared question "the science".