BioDistribution, the Big Illusion
LNP presence is not synonymous with transfection! Endothelial surface exposure is a much more logical way to assess where nanoparticles end up, consistent with observed adverse events.
Summary:
A brief article to bring a different perspective on the Bio-Distribution debate. I have gone down that rabbit hole and came out long ago. Beyond the disbelief of realising “It stays in the muscle!” was a big fat lie, one needs to observe the clinical data of adverse events, and admit it is absolutely not aligned with this distribution. And i…