Most Already Had Robust Immunity - Past Corona Infections Had Already Acted As Universal Vaccines
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Most Already Had Robust Immunity - Past Corona Infections Had Already Acted As Universal Vaccines
Overwhelming proof that cross-immunity existed widely before the arrival of SARS-COV-2 - Vaccines were absolutely unwarranted
Adaptation of an article titled “ Covid-19: Have we been looking in the wrong place?” written December 2020 on Cross-Immunity. This paper intends to provide evidence that the vaccines were never needed, and explains why.
Most of you have probably read the "Survival Bias" story about reinforcing bombers during world war II:
American airforce engineers wanted to enhance the protection of the planes by reinforcing areas where bullets had hit most the planes who had managed flying back home safely. Engineers were focusing on the red bullet points (see illustration).
As statistician Abraham Wald pointed out at the time, armoured plating was required in areas left untouched - the blue circles. Indeed these blue areas were likely the sensitive zones with no coming back when hit: the rudder, the cockpit, the engine and the flaps, and the red areas were less sensitive and could take a hit without destroying the plane.
He was highlighting a complete opposite perspective to what was being proposed!
What's that got to do with Covid?
Collectively, research and the pharmaceutical industry has been making the same mistake on Covid-19 as these well-intended smart American airforce engineers did nearly 80 years ago. They have essentially focused on the wrong information, the non universal part of the genetic material of the virus, which has been found to mutate the most.
In January 2020, SARS-Cov2 was rapidly sequenced (see illustration), and immediately the research community started investigating its novelty (the red dot areas). How was Covid-19 unique? and different from SARS-Cov1? What was its mode of action?... Naturally, research started focusing on the now infamous Spike protein, the foundation for these upcoming mRNA and viral vector vaccines.
But everyone was oblivious of the elephant in the room:
Covid-19 shares 65-82% genome with other Coronaviruses!
Why is this so critical?
Roughly 21,000 nucleotides are shared between SARS-Cov2 and other HCovs. And mild forms of coronaviruses, common colds, are permanently circulating the planet and have been infecting people for centuries: Billions of people have had to gain immunity against the most immunogenic parts of this long string of common RNA.
Past infections have had to act as "vaccination campaigns", only with a universal stable material: immunising against COVID-19 even before it ever existed. The concept is well known: it’s a phenomenon called “Cross-immunity”.
Working in biotech, I am a big believer in biotechnology and the future of mRNA/DNA vaccines, notably in the fight against cancer. And if one believes in mRNA vaccines for Covid; one necessarily needs to believe that past coronaviruses have already immunised a big part of the population. They are based on the same underlying immunological processes.
If one believes in vaccines, one has to believe in acquired immunity from past viral coronavirus infections.
As I have already described in several articles, beyond the breadth of antigen targets (larger from natural immunity), the main difference currently between current vaccines and natural immunity is the fact that natural immunity provides not only systemic immunity - like vaccines - but also sterilising mucosal immunity for a limited period (<2yrs) - which the vaccines do not provide unfortunately.
The most prominent and visible clinical evidence of that sterilising immunity was the wide pervasiveness of the asymptomatic population witnessed throughout the globe, notably in very dense regions like Asia and Africa. Indeed, density-induced incidence levels are so high that a form of permanent immunity seems to exist in these countries through the form of a mucosal sterilising immunity (See Yokohama/Stockhölm). People’s mucus is probably constantly stimulated by low levels of aerosol virus, and people are oblivious of the common colds as was described in Hyderabad where 89% of the infected of SC2 never even realised they had been infected!
Lived density versus Covid death/million (Dec 2020)
There are now ample proofs and demonstrations of pre-existing immunity to SARS-COV2 throughout the world including in the US, the UK, Germany, India, Japan, Singapore, Ecuador, Gabon, Tanzania. This is not anecdotal evidence.
There is overwhelming scientific proof of pre-existing cross immunity to SARS-COV2 across the entire globe
USA / Netherlands / Germany / Singapore / UK
“In 82/88 cases (93.2%), the cells responding to SARS-CoV-2 mesopool stimulation were clearly CD4+ T cells…” - Source
[systemic immunity]
Vancouver - Canada
“…we determined that more than 90% of uninfected adults showed antibody reactivity against the spike protein…” - Source
[systemic immunity]
Berlin - Germany
“HCoV-S-I and S-II-reactive CD4+ T cells were more readily detectable than SARS-CoV-2 spike-specific T-cells and found in 80% (S-I) and 98% (S-II) of SARS-CoV-2 unexposed individuals, respectively.” - Source
[systemic immunity]
Stuttgart - Germany
:“Strikingly, small amounts of SARS-CoV-2-directed T-cells, which recognise virus components, were identified in 81 percent of these unexposed donors.” - source
[systemic immunity]
Detection and characterization of T cell responses to SARS-CoV-2-
derived HLA class I and HLA-DR T cell epitopes in unexposed individuals
New Delhi - India
“…we identified SARS-CoV-2 cross-reactive CD4+ T cells in around 66% of the unexposed individuals…This study provides the evidence of both high magnitude pre-existing and persistent immune memory in Indian population.” - Source
[systemic immunity]
SARS-CoV-2-specific CD4+ T cells response in unexposed donors and recovered COVID-19 patients
Yokohama - Japan
“ The major findings were that 95/180 (53 %) of overall individuals who had not been exposed to SARS-CoV-2 were positive for salivary IgA… ” - Source
[mucosal immunity]
Singapore
“…we detected SARS-CoV-2-specific IFNγ responses in 19 out of 37 unexposed donors…” - Source
[systemic immunity]
Stockhölm - Sweden
“…we detected SARS-CoV-2–reactive mCD4+ and/or mCD8+ T cell responses in 49% of tonsil samples” - Source
[mucosal immunity]
Identification of tonsillar mCD8+ T cells specific for SARS-CoV-2 in unexposed individuals
Boston - USA
“ In fact, CD8+ T cells recognizing nucleocapsid-derived SPRWYFYYL in B*07 (SPR-B07) were found in almost 80% of unexposed subjects.” - Source
[systemic immunity]
Dose-response curves for several rTCRs from COVID patients (left) or unexposed subjects (right) stimulated with peptides from SARS-CoV-2 or HCoV HKU1/OC43
Kansas - USA
“ Forty-one of the 44 adults (94%) and 57 of the 86 children (66%) without prior SARS-CoV-2 infection had detectable IgG antibodies against the SARS-CoV-2 spike S2 subunit; 41 and 46 adults and children had detectable antibodies targeting NP”- Source
[systemic immunity]
This is overwhelming evidence. Health authorities, corrupt biologists and vaccine manufacturers will try to tell you that this is not proof of immunity. And then use a few antibodies to justify vaccine efficacy. Double standards again.
Obviously, the cross-immunity concept doesn’t apply solely to coronaviruses: After the H1N1 epidemic, the La Jolla Institute for Allergy and Immunology already had demonstrated large pre-existing cell immunity against H1N1 from past influenza infections.
You are probably thinking ... So what? (if you've come this far, thanks :-) )
Well the consequences of this validation are far reaching scientifically, but also politically:
THE VAST MAJORITY NEVER NEEDED VACCINATION, because they were already immune. Remember current vaccines provide only systemic immunity, ie reactive, but as proven over and over in the studies above, people already had cross-reactive immunity.
This means THE PANIC WAS UTTERLY UNWARRANTED FOR. Indeed only people whose immune system was dysfunctional were effectively at risk.
Health authorities could have undertaken to assess the level of cross-immunity of the population via blood bank analysis. They never did!! The whole crisis would have been over and done. The fact that they didn’t - or only went after SC2 specific antigens - shows criminal intent, else they are totally incompetent. Many have been highlighting this from the beginning of this crisis.
THEY CAN’T SAY THEY DIDN’T KNOW.The actual spread of the pandemic was widely underestimated and its lethality widely overestimated. That everybody had a sense of... and it’s becoming more and more evident every day.
THERE’S A CHANGE IN VACCINE PARADIGM NEEDED: UNIVERSAL+MUCOSAL: with wider targets, not sensitive to virus mutations, guaranteeing safety and effectiveness for our elderly.
Whether one believes in vaccine effectiveness or not, whether one believes in vaccine safety of not, it’s all irrelevant.
THESE VACCINES WERE NEVER NEEDED for the vast majority of the population, and were recklessly imposed by an incompetent corrupt “elite”, driven by private interests, who wiped out decades-old public health policies, lied to and manipulated our political leaders by presenting an utterly false picture, corrupted their vision and misdirected their decisions to capture enormous public cash.
This mafia-like ecosystem behaved like criminals and those responsible will need to be prosecuted fairly and made accountable for the fear they imposed, for the dramatic cost on our society and for the destruction of so many lives.
The time has come to open our hearts to our families, friends and neighbours who have been betrayed, and to make sure justice is served - with dignity and ethics - on corrupt organisations and people who - evidence shows - have blood on their hands.
“Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans” by Mateus et al
“A majority of uninfected adults show preexisting antibody reactivity against SARS-CoV-2” by Majdoubi et al
“Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination” by Loyal et al
“SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition” by Nelde et al
“Immune Memory in Mild COVID-19 Patients and Unexposed Donors Reveals Persistent T Cell Responses After SARS-CoV-2 Infection” by Ansari et al
“Prevalence of saliva immunoglobulin A antibodies reactive with severe acute respiratory syndrome coronavirus 2 among Japanese people unexposed to the virus” by Tsukinoki et al
“SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls” by Le Bert
“Identification of resident memory CD8+ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue” by Niessl
“Allelic variation in Class I HLA determines pre-existing memory responses to SARS-CoV-2 that shape the CD8+ T cell repertoire upon viral exposure” by Francis et al
“Cross-reactive antibody immunity against SARS-CoV-2 in children and adults” by Fraley et al
Most Already Had Robust Immunity - Past Corona Infections Had Already Acted As Universal Vaccines
an essential contribution to the literature.
Very interesting Marc. Thank you. The point about density and constant incremental exposure was particularly of interest and, I believe, very much under-appreciated. As I have written on twitter a few times, the collective is and has been so fundamental to human survival that it would be odd, and presumably contrary to evolutionary theory, if the group was not also a source of protection even in the case of infectious disease. Of course, this is counter-intuitive to all those, including the majority of the modern medical community, who fail to grasp either the complex-systems elements at work here or the extent of nature's protections.