The Semmelweis Curse
A Rare Outreach from a Fellow Thinker: Unpacking the Depths of the Bolus Theory.
Earlier this week, A Midwestern doctor contacted me via a comment I had made a few months ago on one of his excellent Substacks. He wanted to share a 1989 Chinese study where the researchers had injected a cellular pertussis vaccine directly into the carotid artery1 to consistently trigger a brain edema in rabbits, and then test a direct DMSO injection to see the therapeutic outcome (which ended up positively reducing the edema).
It’s rare that other scientists reach out to me in such an open, collaborative manner; for most, I am just an MBA who only merits ad hominem. I was more surprised by the kindness and unusual nature of the message than by the research itself. This is a testament to his/her goodwill.
A Midwestern doctor seemed surprised that researchers in China in 1989 would use a direct intra-arterial injection to create systematic harm to the brain. The outcome of such a direct injection is clear if one follows the bolus theory; the pertussis vaccine particles would trigger large-scale endothelial damage on the blood-brain barrier, trigger a coagulation cascade, induce microclots as well as leaks in the blood-brain barrier, inflammation, and edema.
After a brief exchange, I realized that he/she wasn’t aware of the overwhelming evidence and validation I have presented and articulated in my book, “The Needle’s Secret,” or in my Substack.
For 4+ years, I have been Semmelweis-ed.
So most still believe the Bolus Theory is just a simple “IV, not IV” dichotomy with no substance, when in reality, the Bolus Theory goes to a level of detail and evidence that is overwhelming.
I thought I would share publicly my final answer to A MidWestern Doctor via my Substack. In this message, I elaborate on the granularity of the Bolus Theory.
I would like to thank him/her for reaching out and for keeping an open mind, and I hope this will prompt a deeper investigation into my work.
Dear A Midwestern Doctor,
Thank you. I sincerely appreciate your kind attention.
My work is under-appreciated, and it certainly doesn’t stop at “IV, not IV” like most people oversimplify.
The Bolus Theory is vastly more nuanced and sophisticated. The root cause analysis I have conducted goes 4 to 5 levels down from that, explaining all the mechanistic steps that lead to adverse reactions in detail, often for the first time:
- First level: The first level of analysis explains why there’s a primary bolus (plunger pressure) and a secondary Bolus (muscle reaction pressure). The Law of Pressure Gradients dictates intravascular leakage. Unequivocally. It proposes various scenarios of invisible IV injections based on severed vessel sizes and locations. I’ve even estimated the size of the primary bolus based on these scenarios. This first level also explains the bolus journey, PEG-erosion (LNP activation), and bolus fragmentation
- Second level: This level explains the susceptibility of harm by the type of cells harmed.
(A) Immune-sensitive cells: large-scale endothelial transfection and subsequent immune-mediated apoptotic damage, and
(B) Immune-privileged cells: abnormal LNP reach in hidden-away stem cell niches and contamination of stem cells.
- Third level: Here, the analysis highlights the direct and indirect consequences locally of the damages above.
A - (1) Repair imbalances subsequent to longitudinal arterial damage;
A - (2) Organ/System dysfunctions due to necrosis or/and blood-tissue barrier breakdown;
B - (3) Aberrant surplus of stem-cells induced by evasion-by-replication strategy post-contamination
;
B - (4) Mitotic contaminant-induced chromosomal damages and modifications (which can include Kevin’s DNA integration as a subset).
- Fourth level: The severity of the local damage can vary based on several factors
A - (a) Severity based on 4 topologies of bolus landing (sieve-like to full carpet bombing)
A - (b) severity based on ischemia-induced necrosis level,
A - (c) severity based on blood-tissue barrier leak size,
A - (d) severity based on landing area sensitivity,
B - (e) severity based on contaminant type and level (cancer),
B - (f) severity based on the scale of the contaminated stem cell (high-ranking multi-potent vs low-ranking progenitor)
B - (g) severity based on age of genetic damage (mosaicism)
- Fifth level: Detailed step-by-step explanation of illness.
(1) Thrombosis, thrombocytopenia, calcifications, aneurysms, white clots, and fistulas can all be explained by repaired imbalances due to considerable longitudinal endothelial damage and misallocated repair factors.
(2) Neurodegenerative diseases, endocrine disorders, reproductive disorders, skin-joint and muscle disorders, autoimmune diseases, bowel inflammatory disorders, and autism... can all be explained by necrotized tissue and/or leaky blood-tissue barriers in the organs or the systems.
(3) Cancer aggressiveness can be associated by the seniority of the stem cell transfected: high-grade cancers are triggered by the contamination of high-ranking undifferentiated stem cells, low-grade cancer by low-ranking differentiated stem cell contamination, non-malignant neoplasms by the lowest ranking progenitor cells.
(4) all genetic disorders: Mito disease, Down syndrome, etc....
An example of the growing sophistication of the bolus theory is the significance of the size of the blood-tissue barrier leak, which allows different types of blood contaminants to enter the tissue based on their size and triggers fundamentally different illnesses.
A small leak will allow peptidic antigens or amyloids to enter, driving IgE-mediated responses and inflammation over time, which often triggers degeneration in the medium-long term.
A larger leak will allow plasma to enter, triggering angiogenesis, scarring, and fibrosis.
Two very different pathologies result from a simple physical difference at the same location. For example, this explains the difference between Eczema and Psoriasis.
Respectfully, if you had had the opportunity to read my book (happy to send it to you btw) or Substack, you would know I have extensive and unequivocal evidence for what I present, as well as all the logical pathological process steps (all supported by Scientific Laws i.e. there are no to very little conjectures in my work; it’s all mostly mechanistic and physics-based).
BBB leakage is also something I looked into in detail as the root cause of neurodegeneration. There is ample evidence and literature in modern-day neurobiology that BBB physical leakage is what leads to neurodegenerative disease. The leak area dictates the illness. The leak predates the illness. If that’s a topic you are interested in, I suggest you read: “Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders.” by Sweeney et al
I have been Semmelweis-ed for 4 years now.
Just like “hand-washing”, “Bolus Theory” is met by the medical and biological research community with a rapid shrug, cognitive dissonance, a “it can’t be the only reason” careless discount, and then aggressively ignored despite the overwhelming evidence.
As you are probably the most open-minded, rigorous, and exhaustive doctor around, I am very appreciative of your reaction to this Chinese experiment and your thoughts on the Bolus Theory.
Doctors knew a century ago that accidental IV injections caused serious adverse reactions with vaccines, or even pollen (BT applies to all injectables).
“Thrombosis of Peripheral Arteries Following the Intravenous Injection of Typhoid Vaccine Report of Two Cases” by Allen et al. - 1929
“The role of accidental puncture of veins in the production of allergic shock” by G. L. Waldbott - 1936
Veterinarians today know and protect cattle better than our children.
“Fatal Adverse Pulmonary Reaction in Calves after Inadvertent Intravenous Vaccination” by Ramsay et al..
I have worked pro bono tirelessly. In all humility, there is considerable knowledge to be gained from my theory, as it highlights the human body’s limits in terms of repairability and explains most, if not all, chronic diseases today.
As a Nobel Prize laureate told me after I had just explained the Bolus Theory, “It’s simple, but you’re gonna face a huge resistance!”. I hope I get the opportunity one day to explain the theory to you.
I apologize for the lengthy message.
Sincerely yours,
Marc Girardot
The Bolus Theory Series
I thought that would be valuable to share with you. I am working on a few other articles. Feel free to comment and ask questions if I wasn’t clear enough. I hope you will all help me break the Semmelweis curse…
Feel free to subscribe to a paying subscription or become a Founding member.
Love, Marc
The carotid arteries are the main blood vessels in your neck that deliver oxygen-rich blood from your heart to your brain, face, and neck. There are two carotid arteries, one on each side of your neck, and each one splits into two main branches: the internal carotid artery, which supplies blood to the brain and eyes, and the external carotid artery, which supplies the face, tongue, and other external parts of the head.



















It is amazing that doctors never question anything. Are they all that brain dead?
“I hope you will all help me break the Semmelweis curse…”
I’ll help you Marc