Poking Holes in the Brain-Blood Barrier. Is that such a good idea?

BBB leakage has been associated with neurodegenerative illnesses; COVID vaccine with vascular leakage. Are we to expect a new wave of Alzheimer's and Parkinson's disease?

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For over a year now, the concern about Covid vaccines adverse effects on our vascular system has been haunting me.

On Team Reality, many of my biologist friends took a very different route of investigation than mine. They all dove into arcane science - well beyond my reach, I admit - trying to explain the extremely wide diversity of pathologies - strokes, myocarditis, thrombosis, neurological disorders, feet blister, tinnitus … - through a rich spectrum of microbiological processes. And, indeed, it is quite mind-stretching to grasp what - and how - the same nanoparticles

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would trigger such distinct pathologies.

However, most scientists have ignored three very fundamental, numerically significant and factual traits about these vaccines:

1. The vascular system is the main area of transfection

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   As 70-80% of the LNPs leak away from muscle tissues into the blood stream, the circulatory system becomes not only their main receptacle, but likely the area where the vast majority of transfections occurs. As such pathologies necessarily originate from vascular damage wherever they take place.

2. Billions of endothelial cells will be destroyed by the immune system
   All the billions of endothelial cells, core constituents of our blood vessels penetrated by the vaccine particles, will end up being attacked and destroyed by the immune system. Both T-cells and NK cells can be trusted, no conjecture. If immunised, naturally or via a prior vaccine injection, the immune attack will be massive and very rapid, within a few hours. Literally “skinning alive” the inner lining of our blood vessels.

3. Concentrated hits impede proper repair of the endothelial walls
   As I explained in “Vaccine Russian Roulette”, pathologies inevitably occur not when immune attacks are distributed and diffuse (leaving time and space for repair), but more likely when they are concentrated, seriously disrupting the endothelial balance: making repair long and uneven, mimicking a cut in the blood vessel, triggering significant coagulation, exposing normally protected cells to the dangers of blood flow and kick-starting a variety of deleterious processes: inflammation, calcification, arteries caving in ... some more immediate, some possibly more long term.

In the next few lines, I will highlight why I believe:

These vaccines have the potential to create a wave of neurodegenerative diseases, adding a new urgency to stop the vaccine dystopia.

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Brain Vasculature Should be the Prime Target of NanoParticles

Utilising 20% of the body’s energy, the humain brain contains ~650 kilometers of blood vessels, roughly 6 times the lungs’ own vascular system. As such it would be natural that the brain would face the most endothelial risk in the human body.

When the data about the LNP distribution came out last year, most of us naturally focused on the organs where most of the nanoparticles seemed to be principally localised: liver, spleen, ovaries, heart, lungs … Strangely, the brain seemed relatively untouched with a peak estimate at 2 million nanoparticles in the brain, whereas the lungs seem to retain 6 times more vaccine particles... an inverted proportion.

The BBB controls what penetrates the brain much more tightly and rigourously. In other words, vaccine particles can come in and out freely in most organs, not in the brain. As long as the brain-blood barrier is leak-proof, very limited quantities of lipid nanoparticles - or pseudo-virus vectors - will penetrate the brain.

As we have witnessed with the escape from the injection point, it doesn’t mean necessarily that tissues are favourable to transfection…so a significant proportion of cytotoxic LNPs accounted for in Chart 1 aren’t necessarily synonymous with severity. Indeed, they might leak back into the lymphatic system and the blood stream later on.

What I am trying to say is that it might seem from Chart 1 that the brain is not so much at risk, but effectively it probably is. Simply the brain isn’t storing LNPs in the tissue the way muscles or the heart might…and therefore the 2 million LNPs accounted for in the brain are likely transfected BBB endothelial cells !

For the record 2 million endothelial cells represent a surface of 26 sq.cm. on a grand total of 12 sq.m. of BBB surface at each injection for Pfizer only. Moderna, AstraZeneca and Jenssen risk 75 sq.cm. at each injection. Between 0.02% and 0.06% of the surface seems negligible, but over time even the mightiest of ships will sink if a tiny leak isn’t repaired.

Worse, as discussed in one of my recent articles, an accidental intravenous injection would increase 100-fold the transfection potential, significantly increasing the direct or indirect risk of harm to the brain.

Transfection Potential Estimate Post Inadvertent Intravenous Injection

Whatever the scenario, at each injection, particularly when the schedule has been very short - i.e. leaving no time for repair - a significant risk exists in poking permanent small holes into the shield that protects our brain.

The brain-blood-barrier is a highly sophisticated platform dedicated entirely to the protection of the human brain. There can be no doubt that protecting the brain and the cerebrospinal fluid - in which the brain is maintained - serves a critical survival purpose.

The work of Professor Burkhardt, German Pathologist, has shown the potential vascular damage of these vaccines on the arteries; evidently similar harm can be inflicted by these Covid vaccines on the brain’s vascular system.

Despite the body’s incredible repair capabilities, we know from scarred skin tissue that repairing heavy cellular damage often ends up with diminished functionalities or flexibility. It is therefore logical - and probable - that the same cause that created arterial damage upstream from the brain, would trigger a comparable deleterious effect on the BBB, threatening the brain’s tightly controlled flow between the blood and the brain.

The depiction of neurodegenerative disorders by today’s researchers ressembles very much what I have been describing happening in other parts of the circulatory system, except here it triggers a different domino effect…harming pericytes, breaking up the interstitial fluid flow, letting in albumin, etc… but the root cause remains endothelial harm.

Click on picture to access “BBB breakdown in Alzheimer disease and other neurodegenerative disorders” by M.Sweenery et al, Nature Neurology - March 2018

For the past few decades, teams throughout the world have investigated the consequences of BBB breakdown. Here is an accessible American Scientific article you might enjoy. What these teams have found is a correlation between BBB permeability and neurodegenerative diseases.

The location of the BBB leak apparently determines the type of degenerative disease:

• Hippocampus → mild cognitive impairment

• Grey & white matter → Alzheimer disease

• Basal ganglia → Parkinson disease

• Caudate nucleus → Huntington disease

• Perivascular lesions → multiple sclerosis

The location of the transfection and its concentration on the endothelial surfaces continue to explain well the adverse effects we have witnessed these past 15 months:

• Heart → myocarditis and pericarditis,

• Lungs→ pulmonary embolism,

• Aorta and arteries → thrombosis, strokes and arterial collapse,

• Liver → hepatitis

• Tendons → tendonitis

• …

The same damage to the BBB - concentrated enough - would inevitably create permanent leaks into the brain, that over time, depending on the severity of the leak, will probably trigger another global epidemic of neurodegenerative diseases.

Though the slow deterioration of the BBB is likely a natural progressive consequence of living a long life (see picture below)…

Credit: Alon Friendman / Daniel Kaufer, Scientific American, May 2021

…it is utterly unacceptable that vaccine manufacturers and public health authorities did not consider the potential damage to the BBB and the atrocious consequences over the lives of millions who will ultimately suffer of neurodegenerative disorders such as Alzheimer, Parkinson and epilepsy.

In my close friends:

• one has been suffering for Parkinson disease for 15 years

• another one has two of her parents progressively slipping into Alzheimer dementia

• two different couples have to deal daily with the torment of seeing one’s child suffering from autism (is autism also caused by BBB leakage?)

Neurodegenerative disease doesn’t fall only on the very old, far from it…

Credit Nature Neurology March 2018

The more sophisticated our healthcare, the more neurodegenerative diseases surround us.

It is quite obvious to me that we need to overhaul entirely our public health view of vaccines technologies - and their delivery - to avoid further collective damage, notably via damage to the brain-blood barrier.

The question that inevitably comes to mind is:

Have past vaccines been the cause behind the explosion

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of neurodegenerative diseases these past decades? It sure is an hypothesis worth investigating.

Have we now made things much worse by precipitating the vaccination of the entire world? Unfortunately, it’s very likely…

Thanks for taking the time to read me. Please make sure you share wide and far.

Love, Marc

1. Here it can be mRNA, DNA, viral vectors and attenuated viruses

2. Transfection is the process by which cells are penetrated by the vaccine vectors: lipid nanoparticle, pseudo-viruses, attenuated viruses…

3. DALYs from Alzheimer’s disease have  more than doubled between 2000 and 2019