Part 1 - My Monte Carlo model shows why rapid delivery sends billions of LNPs straight into the bloodstream — and why slow, gentle injections are dramatically safer
This information is fascinating! I have done hundreds of injections on my horses (IV & IM) and dogs (SQ & IM). I was trained to aspirate and go slow. The initial puncture of the needle is where the pain occurs not from the needle being in place for any length of time. The CDC tells health care providers NOT to aspirate vaxxines which is pull back on the plunger after inserting the needle for an IM injection to make sure you have not hit a blood vessel due to the added pain! Vaxxines and drugs like penicillin should NEVER be injected into a blood vessel. I know someone that had a sick calf. They injected the calf with penicillin and did not aspirate. Shortly after the injection, the calf died. I have given many penicillin injections and even in safe locations, I hit blood at least 3 times. This means that had I not aspirated, I would have at least one DEAD horse and maybe as many as three.
If you don't believe that IM injections need to be apsirated then how do you explain the C-19 vaxxine injured mountain biker that testified at Ron Johnson's hearings who detailed how he tasted metal immediately after getting injected? When he asked the injector about this, the reply was sometimes this happens. In the case of doing IM injections on my horses, I was always in a safe zone that were not supposed to have any large blood vessels. I drew blood at least three times. I would never recommend anyone take an IM injection without aspiration unless it is something like B-12 that is OK to get into a blood vessel.
You need to realize that all injections go IV. All. But when you aspirate, you don't get blood each time.
In other words, likely you are saving your horses more by injecting slowly than by aspirating. Evidently, aspiration is good to avoid anaphylaxis.
The biker, Kyle Warner, had an immediate taste in the mouth, but he didn't get a full dose directly intravenously, else he'd likely be dead or at least would have had an anaphylaxic shock. He was most likely injected very quickly, and it went to the heart and had T-cell destroy endothelial cells in myocardium capillaries.
Aspiration only works when the needle is literally inserted into the vessel; it doesn't protect against the dose going IV (remotely) through pressure
gradients to the severed vessels.
Even if you inject slowly and aspirate, it's likely the aorta and large arteries are somewhat damaged, and occasionally there's an outlier event...which existed in the 60s-70s when aspiration and slow injections were systematic.
Impressive research with sources. I would feel confident to take a copy of this to my physician. This information is pertinent to all who accept these injections. Thank you for the heads up.
Injecting "slowly rather than quickly" a bioweapon falsely presented as $afe and effective is nevertheless what we are reading about here, Marc Girardot. Refusing any and all Injections from the military - pharmafia medical Complex due to their dangerousness is what I would think the researcher should really examine and conclude. Nothing $afe nor effective in these injections.
I don't disagree it would be preferable to stop the COVID vaccines.
I never presented these vaccines as safe or effective.
Actually, we should freeze all the vaccines (even the ones you wouldn't label a bioweapon bc they do the exact same thing for the same reason) and most injectables...but even President Trump hasn't been able to do that...
First, I haven't presented the rest of my Simulation, so you'll have to bear with me. Knowledge is key. Labeling things bioweapons isn't science. I do science.
Second, being binary here is dangerous and counterproductive. People will continue to inject material: Vitamins, antibiotics, etc...baby schedule and they'll have the same outcome (at lower rates) so understanding the details is important, and coming out with contingency hacks is very valuable, I believe.
It’s actually disturbing to follow along a moment by moment assessment of IV leakage and consequent tissue damage due to rapid injection..... which demonstrates vaccine toxicity to its core.
And you haven't seen anything yet, Tom, the next stage of the Simulation shows how we litterally catapult hundreds of thousands of microboluses throughout the body with the unreasonable hope they will always land fragmented...
Safest is no injection. Safer is to inject very slowly after having asspirated to avoid worst case scenarios of direct inserion in a vessel, and that's true for both adults and kids.
Thanks for your efforts which are groundbreaking. I am frequently at health conferences and have asked several doctors if they were familiar with it.
Dr Tenpenny replied that she was and agreed with your findings. A doctor I won’t name (but shares the name of a late comedian) scoffed at the idea that a vaccine could get in the bloodstream (just as you said in the book) and said, “Trust me, I’m a doctor.”
I’m just a layman but it seems like common sense that when something is injected into the body there is absolutely no way to control where it goes. In fact claiming it can be contained seems illogical & the doctor who scoffed strikes me as someone who has given up his critical thinking skills long ago & is not aware of it.
Classic tranquilizer dart! All the way back to the blowgun.
Had to laugh at Covid vaccines from day zero... I knew that a century of influenza vaccination only led to more and more flu shots. Wait for the cure... hah!
You can see the evil setup in the past with the WHO setting standards that skipped aspiration. Safety sacrificed for throughput.
Saskatchewan Health Authority is still rocking this helpful page:
Why we don’t aspirate when we vaccinate
December 1, 2021
Recently the Saskatchewan Health Authority has had a number of individuals ask to have their COVID-19 and influenza vaccines aspirated before being vaccinated. We don’t aspirate vaccinations, and don’t need to.
At times, health professionals will insert a needle in an arm and pull back the needle’s plunger to see if any blood fills the syringe. This is called aspirating, which is useful for providing some medications; and is a way to make sure medication isn’t accidentally injected into a vein or blood vessel, which can be dangerous.
Both the Canadian Immunization Guide and the Saskatchewan Immunization Manual do not recommended aspiration for any immunization. Vaccines are delivered to large muscles in the upper arm or thigh, where there is no risk of nearby veins or large blood vessels. As well, aspiration can cause vaccinations to be more painful, which is something we would all like to avoid.
Simply put, there is no benefit to aspirating vaccinations.
------
Tell me more about: visualizing how particle size shifts lymphatic vs systemic delivery
Short answer: Particle size is one of the strongest determinants of whether LNPs stay local and drain into lymphatics (favoring immune‑priming) or rapidly enter blood and distribute systemically (favoring liver and endothelium). Smaller particles tend to access lymph nodes efficiently; mid‑range particles balance lymphatic drainage and local retention; very large particles remain at the injection site or are taken up by local phagocytes
Mechanism overview
Lymphatic uptake depends on interstitial flow and the ability of particles to enter initial lymphatic capillaries through gaps and valves; systemic uptake depends on access to blood capillaries and opsonization that drives hepatic/splenic clearance. Size interacts with surface chemistry and charge to determine whether a particle is carried by lymph (slow, immune‑focused route) or swept into circulation (fast, liver‑biased route)
Size regimes and expected fate
Size bin Typical fate Practical implication
<10 nm Rapidly diffuses into blood; renal filtration; minimal lymph node targeting Systemic exposure; short circulation time
10–50 nm Efficient lymphatic entry and transport to draining nodes Good for vaccine antigen delivery to APCs
50–150 nm Mixed behavior: partial lymphatic drainage; some systemic uptake Balance between local retention and node delivery
>200 nm Mostly retained at injection site; taken up by local phagocytes Strong local depot effect; less systemic exposure
How to visualize it
Think of interstitial pores as size filters: particles below a threshold slip into lymphatic openings; larger particles are trapped in the matrix and encounter resident macrophages
Imagine two highways: the lymphatic highway is slow and leads to nodes (immune control centers); the blood highway is fast and leads to liver and spleen (clearance hubs)
Overlay surface chemistry: PEGylation and charge shift the effective size and “stickiness,” so two particles with the same diameter can behave differently in vivo
Design tradeoffs (Pfizer/Moderna context)
Smaller, less PEGylated LNPs favor lymph node delivery and stronger local immune priming; larger or more opsonized LNPs favor hepatic uptake and systemic exposure. Both Comirnaty and Spikevax tune size and PEG chemistry to bias toward lymphatic/IM behavior while minimizing systemic spread
Practical takeaway
For vaccines, 10–100 nm is the sweet spot for getting antigen into draining lymph nodes while limiting systemic exposure; shifting size by tens of nanometers meaningfully changes organ targeting and immune outcome
would LNPs merge after time in solution to make bigger particles - i wonder if a 'fresh from the freezer' shot would act differently if it sat on the counter for long enough to sit at room temperature for an hour.
Short answer
Yes — lipid nanoparticles can change over time at room temperature: they can aggregate, fuse, or shed surface PEG, and the encapsulated mRNA can degrade. A single hour at room temperature is unlikely to cause catastrophic fusion for a properly handled, recently thawed vaccine, but longer warm exposure, repeated freeze–thaw, dilution, or vigorous agitation increases the chance of larger particles and reduced potency.
What physically happens to LNPs out of cold storage
Aggregation and fusion — lipid shells can stick together or merge, producing larger particles; this is driven by Brownian collisions, reduced colloidal stability, and loss of steric repulsion.
PEG‑lipid desorption — the PEG layer that stabilizes particles can come off over time, making particles “stickier” and more prone to aggregation and opsonization.
Chemical degradation — ionizable lipids and ester linkages slowly hydrolyze at higher temperatures, changing membrane properties and reducing endosomal escape efficiency.
mRNA degradation — higher temperature and any RNase contamination accelerate mRNA breakage, lowering the amount of intact template available for translation.
How those changes alter biological behavior
Bigger particles drain less well to lymph nodes and are more likely to be retained at the injection site or taken up by local phagocytes rather than delivered to APCs in nodes.
Increased opsonization and hepatic/splenic clearance — aggregated or PEG‑shed particles are cleared faster by macrophages, shifting biodistribution toward liver and spleen and reducing effective antigen expression.
Lower endosomal escape and translation — chemical changes to the ionizable lipid and mRNA loss reduce how much spike protein is produced per dose.
Potentially altered reactogenicity — more uptake by phagocytes and faster clearance can change the inflammatory profile (often more local inflammation), though effects are complex and formulation‑dependent.
Is an hour at room temperature a big deal?
Usually not if you follow manufacturer handling: vaccines are formulated to tolerate the brief handling needed for thawing and preparation. A properly thawed vial left at room temperature for an hour before injection is unlikely to have major particle fusion or complete loss of activity.
But risk rises with: repeated freeze–thaw cycles, leaving vials at warm temperatures for many hours, diluting and then sitting, or vigorous shaking — any of these increase aggregation and mRNA degradation.
Practical implications (what changes in practice would matter)
Fresh‑from‑freezer then thawed and used promptly → minimal change in particle size/function.
Thawed and left at room temp for many hours or repeatedly warmed/cooled → measurable aggregation, reduced lymphatic targeting, lower protein expression, and altered biodistribution.
Dilution and agitation (e.g., vigorous shaking) accelerate instability and should be avoided.
Bottom line
LNPs are engineered for a balance of stability and function. Short, manufacturer‑recommended handling at room temperature is generally safe; extended warm exposure, repeated freeze–thaw, dilution followed by delay, or rough handling increases aggregation, PEG loss, and mRNA degradation — all of which reduce effective delivery and change where and how much spike protein is produced. If you want, I can outline a simple sensitivity table showing how particle size increases (e.g., 50 → 150 nm → 300 nm) shift lymphatic vs systemic delivery and expected functional consequences.
Brilliant Marc, "heavy lifting" may well be the understatement of this very young new year. Nick Hulscher, Dr. Peter McCullough's associate and an excellent researcher himself imho, needs to know about your latest magnum opus re the Bolus Theory. Will do my best to bring it to both of their attention!
Have you addressed insulin injections? Why are they safe, but vaccine injections are not?
I thought I had replied yesterday. My apologies.
insulin doesn't have the cytotoxicity nature of LNPs, but it can aggregate, in which case it can behave similarly to LNPS.
But that wouldn't be the general case.
The pharmacokinetics are very close to epinephrine, with a peak at an hour.
Insulin is supposed to be injected slowly. + Not cytotoxic discretely, I don't think it's a major risk. I could be wrong.
This information is fascinating! I have done hundreds of injections on my horses (IV & IM) and dogs (SQ & IM). I was trained to aspirate and go slow. The initial puncture of the needle is where the pain occurs not from the needle being in place for any length of time. The CDC tells health care providers NOT to aspirate vaxxines which is pull back on the plunger after inserting the needle for an IM injection to make sure you have not hit a blood vessel due to the added pain! Vaxxines and drugs like penicillin should NEVER be injected into a blood vessel. I know someone that had a sick calf. They injected the calf with penicillin and did not aspirate. Shortly after the injection, the calf died. I have given many penicillin injections and even in safe locations, I hit blood at least 3 times. This means that had I not aspirated, I would have at least one DEAD horse and maybe as many as three.
Thank you. Aspiration only helps when the needle is very close to a large enough vessel.
Sadly, it's not helpful in the vast majority of cases.
Injecting very slowly, however, likely prevents many accidents.
Sadly, IM injections remain extremely dangerous, notably for the lungs, the aorta, and the large arteries, even when injecting slowly and aspirating.
If you don't believe that IM injections need to be apsirated then how do you explain the C-19 vaxxine injured mountain biker that testified at Ron Johnson's hearings who detailed how he tasted metal immediately after getting injected? When he asked the injector about this, the reply was sometimes this happens. In the case of doing IM injections on my horses, I was always in a safe zone that were not supposed to have any large blood vessels. I drew blood at least three times. I would never recommend anyone take an IM injection without aspiration unless it is something like B-12 that is OK to get into a blood vessel.
My apologies, I didn't phrase it properly.
You need to realize that all injections go IV. All. But when you aspirate, you don't get blood each time.
In other words, likely you are saving your horses more by injecting slowly than by aspirating. Evidently, aspiration is good to avoid anaphylaxis.
The biker, Kyle Warner, had an immediate taste in the mouth, but he didn't get a full dose directly intravenously, else he'd likely be dead or at least would have had an anaphylaxic shock. He was most likely injected very quickly, and it went to the heart and had T-cell destroy endothelial cells in myocardium capillaries.
Aspiration only works when the needle is literally inserted into the vessel; it doesn't protect against the dose going IV (remotely) through pressure
gradients to the severed vessels.
Even if you inject slowly and aspirate, it's likely the aorta and large arteries are somewhat damaged, and occasionally there's an outlier event...which existed in the 60s-70s when aspiration and slow injections were systematic.
WHat I meant is aspiration is no panacea.
Impressive research with sources. I would feel confident to take a copy of this to my physician. This information is pertinent to all who accept these injections. Thank you for the heads up.
Injecting "slowly rather than quickly" a bioweapon falsely presented as $afe and effective is nevertheless what we are reading about here, Marc Girardot. Refusing any and all Injections from the military - pharmafia medical Complex due to their dangerousness is what I would think the researcher should really examine and conclude. Nothing $afe nor effective in these injections.
I don't disagree it would be preferable to stop the COVID vaccines.
I never presented these vaccines as safe or effective.
Actually, we should freeze all the vaccines (even the ones you wouldn't label a bioweapon bc they do the exact same thing for the same reason) and most injectables...but even President Trump hasn't been able to do that...
First, I haven't presented the rest of my Simulation, so you'll have to bear with me. Knowledge is key. Labeling things bioweapons isn't science. I do science.
Second, being binary here is dangerous and counterproductive. People will continue to inject material: Vitamins, antibiotics, etc...baby schedule and they'll have the same outcome (at lower rates) so understanding the details is important, and coming out with contingency hacks is very valuable, I believe.
It’s actually disturbing to follow along a moment by moment assessment of IV leakage and consequent tissue damage due to rapid injection..... which demonstrates vaccine toxicity to its core.
And you haven't seen anything yet, Tom, the next stage of the Simulation shows how we litterally catapult hundreds of thousands of microboluses throughout the body with the unreasonable hope they will always land fragmented...
The human skin is a barrier and protector. To pierce it with needles and inject criminal toxic substances is insane.
I still don't get, which is safer? Slow for babies? Fast for adults?
Safest is no injection. Safer is to inject very slowly after having asspirated to avoid worst case scenarios of direct inserion in a vessel, and that's true for both adults and kids.
Thanks for your efforts which are groundbreaking. I am frequently at health conferences and have asked several doctors if they were familiar with it.
Dr Tenpenny replied that she was and agreed with your findings. A doctor I won’t name (but shares the name of a late comedian) scoffed at the idea that a vaccine could get in the bloodstream (just as you said in the book) and said, “Trust me, I’m a doctor.”
I’m just a layman but it seems like common sense that when something is injected into the body there is absolutely no way to control where it goes. In fact claiming it can be contained seems illogical & the doctor who scoffed strikes me as someone who has given up his critical thinking skills long ago & is not aware of it.
Classic tranquilizer dart! All the way back to the blowgun.
Had to laugh at Covid vaccines from day zero... I knew that a century of influenza vaccination only led to more and more flu shots. Wait for the cure... hah!
You can see the evil setup in the past with the WHO setting standards that skipped aspiration. Safety sacrificed for throughput.
Saskatchewan Health Authority is still rocking this helpful page:
Why we don’t aspirate when we vaccinate
December 1, 2021
Recently the Saskatchewan Health Authority has had a number of individuals ask to have their COVID-19 and influenza vaccines aspirated before being vaccinated. We don’t aspirate vaccinations, and don’t need to.
At times, health professionals will insert a needle in an arm and pull back the needle’s plunger to see if any blood fills the syringe. This is called aspirating, which is useful for providing some medications; and is a way to make sure medication isn’t accidentally injected into a vein or blood vessel, which can be dangerous.
Both the Canadian Immunization Guide and the Saskatchewan Immunization Manual do not recommended aspiration for any immunization. Vaccines are delivered to large muscles in the upper arm or thigh, where there is no risk of nearby veins or large blood vessels. As well, aspiration can cause vaccinations to be more painful, which is something we would all like to avoid.
Simply put, there is no benefit to aspirating vaccinations.
------
Tell me more about: visualizing how particle size shifts lymphatic vs systemic delivery
Short answer: Particle size is one of the strongest determinants of whether LNPs stay local and drain into lymphatics (favoring immune‑priming) or rapidly enter blood and distribute systemically (favoring liver and endothelium). Smaller particles tend to access lymph nodes efficiently; mid‑range particles balance lymphatic drainage and local retention; very large particles remain at the injection site or are taken up by local phagocytes
Mechanism overview
Lymphatic uptake depends on interstitial flow and the ability of particles to enter initial lymphatic capillaries through gaps and valves; systemic uptake depends on access to blood capillaries and opsonization that drives hepatic/splenic clearance. Size interacts with surface chemistry and charge to determine whether a particle is carried by lymph (slow, immune‑focused route) or swept into circulation (fast, liver‑biased route)
Size regimes and expected fate
Size bin Typical fate Practical implication
<10 nm Rapidly diffuses into blood; renal filtration; minimal lymph node targeting Systemic exposure; short circulation time
10–50 nm Efficient lymphatic entry and transport to draining nodes Good for vaccine antigen delivery to APCs
50–150 nm Mixed behavior: partial lymphatic drainage; some systemic uptake Balance between local retention and node delivery
>200 nm Mostly retained at injection site; taken up by local phagocytes Strong local depot effect; less systemic exposure
How to visualize it
Think of interstitial pores as size filters: particles below a threshold slip into lymphatic openings; larger particles are trapped in the matrix and encounter resident macrophages
Imagine two highways: the lymphatic highway is slow and leads to nodes (immune control centers); the blood highway is fast and leads to liver and spleen (clearance hubs)
Overlay surface chemistry: PEGylation and charge shift the effective size and “stickiness,” so two particles with the same diameter can behave differently in vivo
Design tradeoffs (Pfizer/Moderna context)
Smaller, less PEGylated LNPs favor lymph node delivery and stronger local immune priming; larger or more opsonized LNPs favor hepatic uptake and systemic exposure. Both Comirnaty and Spikevax tune size and PEG chemistry to bias toward lymphatic/IM behavior while minimizing systemic spread
Practical takeaway
For vaccines, 10–100 nm is the sweet spot for getting antigen into draining lymph nodes while limiting systemic exposure; shifting size by tens of nanometers meaningfully changes organ targeting and immune outcome
would LNPs merge after time in solution to make bigger particles - i wonder if a 'fresh from the freezer' shot would act differently if it sat on the counter for long enough to sit at room temperature for an hour.
Short answer
Yes — lipid nanoparticles can change over time at room temperature: they can aggregate, fuse, or shed surface PEG, and the encapsulated mRNA can degrade. A single hour at room temperature is unlikely to cause catastrophic fusion for a properly handled, recently thawed vaccine, but longer warm exposure, repeated freeze–thaw, dilution, or vigorous agitation increases the chance of larger particles and reduced potency.
What physically happens to LNPs out of cold storage
Aggregation and fusion — lipid shells can stick together or merge, producing larger particles; this is driven by Brownian collisions, reduced colloidal stability, and loss of steric repulsion.
PEG‑lipid desorption — the PEG layer that stabilizes particles can come off over time, making particles “stickier” and more prone to aggregation and opsonization.
Chemical degradation — ionizable lipids and ester linkages slowly hydrolyze at higher temperatures, changing membrane properties and reducing endosomal escape efficiency.
mRNA degradation — higher temperature and any RNase contamination accelerate mRNA breakage, lowering the amount of intact template available for translation.
How those changes alter biological behavior
Bigger particles drain less well to lymph nodes and are more likely to be retained at the injection site or taken up by local phagocytes rather than delivered to APCs in nodes.
Increased opsonization and hepatic/splenic clearance — aggregated or PEG‑shed particles are cleared faster by macrophages, shifting biodistribution toward liver and spleen and reducing effective antigen expression.
Lower endosomal escape and translation — chemical changes to the ionizable lipid and mRNA loss reduce how much spike protein is produced per dose.
Potentially altered reactogenicity — more uptake by phagocytes and faster clearance can change the inflammatory profile (often more local inflammation), though effects are complex and formulation‑dependent.
Is an hour at room temperature a big deal?
Usually not if you follow manufacturer handling: vaccines are formulated to tolerate the brief handling needed for thawing and preparation. A properly thawed vial left at room temperature for an hour before injection is unlikely to have major particle fusion or complete loss of activity.
But risk rises with: repeated freeze–thaw cycles, leaving vials at warm temperatures for many hours, diluting and then sitting, or vigorous shaking — any of these increase aggregation and mRNA degradation.
Practical implications (what changes in practice would matter)
Fresh‑from‑freezer then thawed and used promptly → minimal change in particle size/function.
Thawed and left at room temp for many hours or repeatedly warmed/cooled → measurable aggregation, reduced lymphatic targeting, lower protein expression, and altered biodistribution.
Dilution and agitation (e.g., vigorous shaking) accelerate instability and should be avoided.
Bottom line
LNPs are engineered for a balance of stability and function. Short, manufacturer‑recommended handling at room temperature is generally safe; extended warm exposure, repeated freeze–thaw, dilution followed by delay, or rough handling increases aggregation, PEG loss, and mRNA degradation — all of which reduce effective delivery and change where and how much spike protein is produced. If you want, I can outline a simple sensitivity table showing how particle size increases (e.g., 50 → 150 nm → 300 nm) shift lymphatic vs systemic delivery and expected functional consequences.
Brilliant Marc, "heavy lifting" may well be the understatement of this very young new year. Nick Hulscher, Dr. Peter McCullough's associate and an excellent researcher himself imho, needs to know about your latest magnum opus re the Bolus Theory. Will do my best to bring it to both of their attention!
Excellent work, Marc, once again! You need to get your work to RFK and Steve Kirsch asap! God Bless you and Thanks so very much for your hard work.